摘要
目的:分析连理汤联合美沙拉嗪对溃疡性结肠炎患者临床疗效的影响。方法:选取河北以岭医院2020年2月-2021年2月收治的100例溃疡性结肠炎患者,以随机数字表法分为2组,每组各50例。对照组用美沙拉嗪治疗,观察组用连理汤联合美沙拉嗪治疗,治疗4周后对比2组的疗效差异。结果:观察组总有效率为94.00%(47/50),大于对照组的80.00%(40/50),差异有统计学意义(P<0.05);观察组复发率为4.00%,小于对照组的14.00%,差异有统计学意义(P<0.05)。治疗前2组患者的中医症状积分、氧化应激指标、炎症细胞因子水平比较差异无统计学意义(P>0.05);治疗4周后各指标均较治疗前明显改善,观察组的中医症状积分均较对照组降低,差异有统计学意义(P<0.05);观察组的超氧化物歧化酶、谷胱甘肽过氧化物酶水平增加,丙二醛水平降低,与对照组比较均差异有统计学意义(均P<0.05);治疗4周后,与对照组比较,观察组肿瘤坏死因子-α、IL-6、IL-1β水平均降低,均差异有统计学意义(均P<0.05);观察组头痛发生率为4.00%、头晕发生率为2.00%、乏力发生率为4.00%、胃部不适发生率为6.00%,与对照组的2.00%、4.00%、4.00%、4.00%比较,均差异无统计学意义(P>0.05)。结论:连理汤联合美沙拉嗪治疗溃疡性结肠炎疗效更佳且不良反应发生率低,值得临床推广应用。
Objective: To analyze the effect of Lianli Decoction combined with mesalazine on the clinical efficacy of patients with ulcerative colitis. Methods: A total of 100 patients with ulcerative colitis who were admitted to Hebei Yiling Hospital from February 2020 to February 2021 were selected and divided into two groups with 50 cases by random number table. The control group was treated with mesalazine, and the observation group was treated with Lianli Decoction combined with mesalazine. The difference in efficacy was compared after 4 weeks. Results: The total effective rate of the observation group was 94.00%(47/50), which was higher than 80.00%(40/50)of the control group, and the recurrence rate was 4.00%, which was lower than that of the control group 14.00%. The difference was statistically significant(P<0.05);Before treatment, the Traditional Chinese Medicine symptom scores, oxidative stress indicators, and inflammatory cytokine values of the two groups of patients were the same. After 4 weeks of treatment, they were all significantly improved compared with this group before treatment. The improvement effect of the observation group was better than that of the control group, and the differences were statistically significant(P<0.05);The observation group had headache incidence 4.00%, dizziness incidence 2.00%, fatigue incidence 4.00%, stomach incidence of internal discomfort was 6.00%, and compared with the control group 2.00%, 4.00%, 4.00%, 4.00%, the difference was not statistically significant(P>0.05). Conclusion: Lianli Decoction combined with mesalazine has a better curative effect in the treatment of ulcerative colitis, and the incidence of adverse reactions is low, which has broad prospects for promotion and use.
作者
鄂辉
杨娇
杨泽江
严晓红
刘雅丽
E Hui;YANG Jiao;YANG Zejiang;YAN Xiaohong;LIU Yali(Department of Spleen and Stomach,Hebei Yiling Hospital,Shijiazhuang,050000,China;Department of Gastroenterology,Qianxi County Peoples Hospital)
出处
《中国中西医结合消化杂志》
CAS
2021年第11期778-782,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
溃疡性结肠炎
连理汤
美沙拉嗪
不良反应
ulcerative colitis
Lianli Decoction
mesalazine
adverse reaction
