摘要
苦参碱和氧化苦参碱能浓度相关地抑制人视网膜母细胞瘤和翼状胬肉成纤维细胞的增殖并诱导细胞凋亡,作用机制可能与激活内质网应激的PERK/ATF4/CHOP信号通路和抑制PI3K/Akt信号通路有关。苦参碱和氧化苦参碱也能浓度相关地抑制角膜成纤维细胞增殖并诱导细胞凋亡以及防治糖尿病视网膜病变和增殖性玻璃体视网膜病变。苦参碱能抑制角膜移植后机体的排斥反应以及防治感染性和非感染性眼炎、准分子激光屈光性角膜切削术术后的雾状浑浊、后发性白内障和眼压升高。综述苦参碱和氧化苦参碱防治眼病药理作用的研究进展,以期为开发眼科新药提供依据。
Matrine and oxymatrine inhibit proliferation in association with dosage on retinoblastoma cells and pterygium fibroblasts,and induce apoptosis.Their mechanism may be related to excite endoplasmic reticulum stress PERK/ATF4/CHOP signaling pathway,and inhibit PI3 K/Akt signaling pathway.Matrine and oxymatrine inhibit proliferation in association with dosage on corneal fibroblasts and induce apoptosis,and prevent and treat for diabetic retinopathy and proliferative vitreoretinopathy.Matrine inhibits bodily reject reaction after corneal allograft,and prevent and treat for infective and non-infective ophthalmitis,haze after PRK,posterior capsular opacification and increasing of intraocular pressue.The effects of matrine and oxymatrine to prevent and treat for ophthalmopathy were reviewed,in order to provide basis for the development of new ophthalmic drugs.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《药物评价研究》
CAS
2021年第9期2041-2048,共8页
Drug Evaluation Research
