摘要
胰腺癌是常见的消化道恶性肿瘤,因其隐匿性强且缺乏早期诊断指标,患者生存率极低。胰腺癌的发病机制尚不明确,吸烟、家族史、糖尿病和肥胖可能与其发生相关,其中2型糖尿病(T2DM)和胰腺癌常合并发生。胰岛素抵抗及代偿性高胰岛素血症是T2DM的主要代谢特征,在胰腺癌的发生发展过程中可能起重要促进作用。本文就胰岛素抵抗及高胰岛素血症促进胰腺癌发生的分子机制进行综述,为胰腺癌防治供依据。
Pancreatic cancer is a common digestive tract carcinoma.It is strongly occult and lack of early diagnostic indicators,and the patients have quite low survival rates.The pathogenesis of pancreatic cancer remains unclear.It has been reported that smoking,family history,diabetes mellitus and obesity are associated with the incidence of pancreatic cancer;moreover,type 2 diabetes mellitus(T2 DM)often occur as a comorbidity.Insulin resistance and compensatory hyperinsulinemia are the main metabolic characteristics of T2 DM,which play an important role in the development and progression of pancreatic cancer.The molecular mechanisms of insulin resistance and hyperinsulinemia promoting pancreatic cancer are reviewed in this paper,in order to provide the evidence for the prevention and treatment of pancreatic cancer.
作者
李珊珊(综述)
赵钰岚(审校)
LI Shanshan;ZHAO Yulan(Zhejiang Provincial Key Laboratory of Pancreatic Disease,the First Affiliated Hospital to School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China)
出处
《预防医学》
2021年第11期1122-1125,1129,共5页
CHINA PREVENTIVE MEDICINE JOURNAL
关键词
胰腺癌
胰岛素抵抗
高胰岛素血症
2型糖尿病
pancreatic cancer
insulin resistance
hyperinsulinemia
type 2 diabetes mellitus
