摘要
目的:探讨及分析各因素间乳腺癌术后患者失眠患病率的差异及各因素与乳腺癌术后继发失眠的相关性。方法:选取2018年1月至2019年9月初次就诊于中日友好医院万冬桂主任医师乳腺癌门诊的女性乳腺癌术后患者,对其进行体质调查,统计纳入患者基本信息,比较不同年龄段、乳腺癌分型、治疗方案及体质类型乳腺癌术后失眠患病率差异,运用χ^(2)检验及Logistic回归分析比较各因素间乳腺癌术后失眠差异,分析各因素与乳腺癌术后患者失眠的相关性。结果:年龄段为≤30岁的乳腺癌术后患者继发失眠患病率(75.00%)远高于其他年龄段;肿瘤分子类型中Luminal型与非Luminal型比较,失眠发病差异有统计学意义(χ^(2)=7.191,P=0.007);是否为Luminal型与失眠的发病存在显著相关性(P=0.008,OR为1.908,95%CI[1.185,3.071]),其中Luminal A型术后失眠患病率最高(71.43%);治疗方法中接受内分泌治疗的乳腺癌术后患者容易出现继发失眠(71.08%);不同体质类型继发失眠差异有统计学意义(χ^(2)=31.738,P=0.000),且中医体质类型与乳腺癌术后继发失眠具有显著相关性(P=0.03,OR为1.006,95%CI[1.005,1.130]),其中阴虚质、湿热质患者失眠的患病率相较于其他体质更高(65.55%及60.98%)。结论:乳腺癌分子类型、体质类型与乳腺癌术后继发失眠明显相关。
Objective:To explore the difference about the incidence rate of insomnia among breast cancer patients after operation and to analyze the correlation between various factors and postoperative insomnia after breast cancer radical operation.Methods:Through selecting the female breast cancer patients after operation between January 2018 and December 2019,who is the first accept the outpatient service of WAN Dong-gui,a doctor of China-Japan Friendship Hospital.We made the physical survey,recorded the incidence and basic information of the patients.To compare the difference in the incidence rate of insomnia among breast cancer patients after operation,different age groups,different breast cancer types,different breast cancer treatment regimens and different physical types.To analysis the difference and correlation factors among the breast cancer patients after operation with insomnia byχ^(2) test and Logistic regression analysis.Results:The incidence of insomnia in breast cancer patients with the age≤30 years old was significantly higher than the other groups(75.00%);There was a difference about the incidence of insomnia between Luminal type and non-Luminal type(χ^(2)=7.191,P=0.007),and there was a significant correlation between the type and the incidence of insomnia(P=0.008,OR=1.908,95%CI[1.185,3.071]).The highest incidence of insomnia happened in Luminal A(71.43%),and the treatment method also showed that the breast cancer patients after operation,who received endocrine therapy,were prone to suffer from insomnia(71.08%).There was a significant difference between different types of constitution(χ^(2)=31.738,P=0.000),and there was a significant correlation between the type of constitution of traditional Chinese medicine and the incidence of insomnia(P=0.03,OR=1.006,95%CI[1.005,1.130]).And the prevalence of insomnia in breast cancer patients with yin deficiency or phlegm-heat was higher than the others(65.55%and 60.98%).Conclusion:There is a significant correlation between Luminal type and non-Luminal type,as well as physical type and insomnia after breast cancer operation.
作者
刘翠芳
万冬桂
LIU Cui-fang;WAN Dong-gui(Department of Geriatric Disease,Miyun Traditional Chinese Medical Hospital,Beijing,Beijing 101500,China;The Oncology Department of Chinese and Modern Medicine of China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第10期6188-6192,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
乳腺癌
失眠
体质类型
相关性
Breast cancer
Insomnia
Constitution type
Correlation
