摘要
目的观察布托啡诺联合右美托咪定超前镇痛对乳腺癌保乳手术患者术后镇痛的效果。方法采用随机数表法将150例接受保乳手术的乳腺癌患者随机分成2组,观察组和对照组,每组各75例。麻醉诱导前,对照组给予静脉泵注布托啡诺注射液1 mg,并在15 min内注射完毕。观察组在对照组基础上,联合注射右美托咪定0.5μg/kg。记录诱导后、切皮、拔管时血压、心率。记录手术时间、出血量、输液量,术后24小时内的平均疼痛评分和不良反应。结果2组患者组间及组内各时间点平均动脉压和心率差异无统计学差异(P>0.05);与对照组比较,观察组术后4~24 h静息和活动NRS评分均明显降低(P<0.05),但术后48 h 2组静息和活动NRS评分差异无统计学意义(P>0.05)。观察组患者在术后眩晕和恶心呕吐的发生率明显低于对照组,差异有统计学意义(P<0.05);2组均无呼吸抑制发生,且住院天数差别无统计学意义(P>0.05)。结论布托啡诺联合右美托咪定超前镇痛对乳腺癌保乳手术患者术后镇痛的效果良好,可以用于乳腺癌保乳手术患者超前镇痛。
Objective To observe the preemptive analgesia effect of butorphanol combined with dexmedetomidine on patients with breast cancer undergoing breast conserving surgery.Methods 150 breast cancer patients underwent breast conserving surgery were randomly divided into 2 groups,the observation group and the control group,75 cases in each group.Before anesthesia induction,the control group was given butorphanol injection 1 mg by intravenous pump,and the injection was completed within 15 minutes.The observation group was given dexmedetomidine 0.5μg/kg on the basis of the control group.Blood pressure and heart rate were recorded after induction,skin incision and extubation.The operation time,blood loss,infusion volume,average pain score and adverse reactions within 24 hours after operation were recorded.Results There was no significant difference in mean arterial pressure and heart rate between the 2 groups at each time point(P>0.05);compared with the control group,the resting and active NRS scores at 4-24 h after operation in the observation group were significantly lower(P<0.05),but there was no significant difference in resting and active NRS scores at 48 h after operation in the H2 group(P>0.05).The incidence of postoperative vertigo and nausea and vomiting in the observation group was significantly lower than that of the control group,the difference was statistically significant(P<0.05);there was no respiratory depression in the 2 groups,and the difference in hospital stay was not statistically significant(P>0.05).Conclusion Butorphanol combined with dexmedetomidine preemptive analgesia has good effect on postoperative analgesia in patients with breast conserving surgery for breast cancer,which can be used for preemptive analgesia in patients with breast conserving surgery for breast cancer.
作者
赵永杰
吴永伟
屈翰
ZHAO Yongjie;WU Yongwei;QU Han(General Hospital of Shenma Medical Group,Pingdingshan,467000)
出处
《实用癌症杂志》
2021年第11期1810-1812,1817,共4页
The Practical Journal of Cancer
基金
2019年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20190933)。
关键词
布托啡诺
右美托咪定
超前镇痛
乳腺癌手术
Butorphanol
Dexmedetomidine
Preemptive analgesia
Breast cancer surgery