摘要
目的探究甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血的临床疗效。方法选取100例围绝经期功能性子宫出血患者,按照治疗方法不同将其分为试验组与对照组,各50例。对照组采用米非司酮治疗,试验组采用甲基睾丸素联合米非司酮治疗。对比两组患者临床疗效、治疗前后性激素水平、雌激素受体(ER)、孕激素受体(PR)、子宫内膜厚度、血红蛋白水平及不良反应发生情况。结果试验组总有效率为92.00%,显著高于对照组的74.00%,差异具有统计学意义(P<0.05)。治疗前,两组抗苗勒管激素(AMH)、促黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E_(2))水平对比,差异无统计学意义(P>0.05);治疗后,两组AMH、LH、E_(2),P、FSH水平均低于治疗前,且试验组明显低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组雌激素受体、孕激素受体对比,差异无统计学意义(P>0.05);治疗后,两组雌激素受体、孕激素受体显著低于治疗前,且试验组明显低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血红蛋白水平、子宫内膜厚度对比,差异无统计学意义(P>0.05);治疗后,两组血红蛋白水平明显高于治疗前,子宫内膜厚度明显薄于治疗前,且试验组明显优于对照组,差异具有统计学意义(P<0.05)。试验组不良反应发生率为4.00%,明显低于对照组的18.00%,差异有统计学意义(P<0.05).结论甲基睾丸素联合米非司酮治疗围绝经期功能性子宫出血的临床效果显著,可改善患者性激素水平,降低子宫内膜厚度,且安全性较高,值得临床推广。
Objective To explore the efficacy of methyl testosterone combined with mifepristone in the treatment of perimenopausal functional uterine bleeding.Methods 100 patients with perimenopausal functional uterine bleeding were selected and divided into experimental group and control group according to difierent treatment methods,50 cases in each group.The control group was treated with mifepristone,and the experimental group was treated with methyltestosterone combined with mifepristone.Clinical efficacy,sex hormone level,estrogen receptor(ER),progesterone receptor(PR),endometrial thickness,hemoglobin level and the occurrence of adverse reactions were compared between 2 groups before and after treatment.Results The total effective rate of experimental group was 92.00%,which was significantly higher than that of control group(74.00%),the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of anti-Mullerian hormone(AMH),luteinizing hormone(LH),follicle stimulating hormone(FSH),progesterone(P)and estradiol(E_(2))between 2 groups(P>0.05).After treatment,the levels of AMH,LH,E_(2),P and FSH in 2 groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in estrogen receptor and progesterone receptor between the two groups(P>0.05).After treatment,estrogen receptor and progesterone receptor in 2 groups were significantly lower than before treatment,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in hemoglobin level and endometrial thickness between the two groups(P>0.05).After treatment,the hemoglobm level of the two groups was significantly higher than before treatment,and the endometrial thickness was significantly thinner than before treatment,and the experimental group was significantly better than the control group,with statistical significance(P<0.05).The incidence of adverse reactions in experimental group was 4.00%,which was significantly lower than that in control group(18.00%),and the difference was statistically significant(P<0.05).Conclusion Methyltestosterone combined with mifepristone in the treatment of perimenopausal functional uterine bleeding has a significant clinical effect,can improve the level of sex hormones,reduce endometrial thickness,and high safety,worthy of clinical promotion.
作者
王昕煜
Wang Xinyu(Department of Obstetrics and Gynecology,The Third People's Hospital of Dafeng District,Yancheng 224100,China)
出处
《实用妇科内分泌电子杂志》
2021年第11期69-72,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
围绝经期功能性子宫出血
甲基睾丸素
米非司酮
临床疗效
Perimenopausal functional uterine bleeding
Methyltestosterone
Mifepristone
Clinical curative effect
