摘要
目的:探讨胃铋镁四联疗法在幽门螺杆菌(Hp)阳性胃溃疡患者中的作用。方法:选取2019年4月至2020年4月宜春市中医院就诊的80例Hp阳性胃溃疡患者,根据随机数字表法分为两组,各40例。对照组采用三联疗法,观察组使用胃铋镁四联疗法,对比两组临床疗效、炎性因子水平、Hp根除率与不良反应。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组白细胞介素-4(IL-4)、C反应蛋白(CRP)比较,差异无统计学意义(P>0.05);治疗后,观察组IL-4、CRP低于对照组,差异有统计学意义(P<0.05);观察组Hp根除率高于对照组,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:胃铋镁四联疗法在Hp阳性胃溃疡患者中作用明显,可显著降低其机体炎性因子水平,有效清除Hp,加快溃疡愈合。
Objective:To investigate the effect of gastric bismuth-magnesium quadruple therapy in patients with Helicobacter pylori(Hp)positive gastric ulcer.Methods:From April 2019 to April 2020,80 patients with Hp positive gastric ulcer in Yichun Hospital of Traditional Chinese Medicine were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group was treated with triple therapy,and the observation group was treated with gastric bismuth-magnesium quadruple therapy.The clinical efficacy,inflammatory factor levels,Hp eradication rate and adverse reactions of the two groups were compared.Results:The total effective rate of observation group was higher than control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in interleukin-4(IL-4)and C-reactive protein(CRP)between the two groups(P>0.05).After treatment,IL-4 and CRP in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The eradication rate of Hp in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Gastric bismuth-magnesium quadruple therapy has an obvious effect on patients with Hp positive gastric ulcer,which can significantly reduce the level of inflammatory factors in the body,effectively remove Hp and accelerate ulcer healing.
作者
孙阳胜
彭启安
罗双莲
SUN Yangsheng;PENG Qi'an;LUO Shuanglian(Yichun Hospital of Traditional Chinese Medicine,Yichun Jiangxi 336000,China)
出处
《药品评价》
CAS
2021年第19期1198-1200,共3页
Drug Evaluation
基金
宜春市科技计划项目(JXYC2020KSA036)。
关键词
胃溃疡
幽门螺杆菌
胃铋镁
炎性因子
Stomach ulcer
Helicobacter pylori
Bismuth magnesian stomach
Inflammatory cytokines
