摘要
目的:观察坤复康片联合西药治疗慢性盆腔炎的治疗效果及对氧化应激因子的影响。方法:按照随机数字表法将128例慢性盆腔炎患者分为试验组与对照组,各64例。对照组给予头孢曲松钠、甲硝唑常规西药治疗,试验组在对照组基础上给予坤复康片治疗。比较2组临床疗效及治疗前后丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、白细胞介素-2(IL-2)、白细胞介素-21(IL-21)、肿瘤坏死因子-α(TNF-α)、中医证候积分情况。结果:试验组临床总有效率93.75%,明显高于对照组81.25%。(P<0.05)。与同组治疗前比较,治疗后2组MDA、AOPP、IL-2、IL-21、TNF-α水平及中医证候积分均降低(P<0.05),SOD水平升高(P<0.05);与对照组治疗后比较,试验组治疗后MDA、AOPP、IL-2、IL-21、TNF-α水平及中医证候积分均较低(P<0.05),SOD水平较高(P<0.05)。结论:坤复康片联合西药治疗慢性盆腔炎可显著提高患者临床疗效,有效减轻氧化应激和炎性应激反应,改善患者临床症状。
Objective:To observe the therapeutic effect of the therapy of Kunfukang tablets combined with western medicine on chronic pelvic inflammatory disease and its effect on oxidative stress factors.Methods:According to the random number table method,128 patients with chronic pelvic inflammatory disease were divided into the experiment group and the control group,64 cases in each group.The control group was treated with ceftriaxone sodium and metronidazole,and the experiment group was additionally treated with Kunfukang tablets based on the treatment of the control group.The clinical effect,malondialdehyde(MDA),advanced oxidized protein product(AOPP),superoxide dismutase(SOD),interleukin-2(IL-2),interleukin-21(IL-21),tumor necrosis factor-α(TNF-α)and Chinese medicine syndrome scores before and after treatment were compared between the two groups.Results:The total effective rate was 93.75%in the experiment group,significantly higher than that of 81.25%in the control group(P<0.05).Compared with those before treatment,the levels of MDA,AOPP,IL-2,IL-21,TNF-αand Chinese medicine syndrome scores in both groups were decreased after treatment(P<0.05),and the levels of SOD were increased(P<0.05);Compared with those in the control group after treatment,the levels of MDA,AOPP,IL-2,IL-21,TNF-αand Chinese medicine syndrome scores in the experiment group were lower(P<0.05),and the level of SOD was higher(P<0.05).Conclusion:The therapy of Kunfukang tablets combined with western medicine for chronic pelvic inflammatory disease can significantly improve the clinical effect,effectively reduce oxidative stress and inflammatory stress response,as well as improve the clinical symptoms of patients.
出处
《新中医》
CAS
2021年第21期147-150,共4页
New Chinese Medicine
关键词
慢性盆腔炎
坤复康片
头孢曲松钠
甲硝唑
氧化应激
Chronic pelvic inflammatory disease
Kunfukang tablets
Ceftriaxone sodium
Metronidazole
Oxidative stress
