摘要
目的探讨亮丙瑞林对子宫肌瘤患者血清胰岛素样生长因子1(IGF-1)、血管内皮生长因子(VEGF)及性激素水平的影响。方法选取2019年1月至2020年1月广东惠阳三和医院收治的70例子宫肌瘤患者作为研究对象,按照随机数字表法分为观察组(35例)和对照组(35例)。观察组采用亮丙瑞林治疗,对照组采用米非司酮治疗。比较两组患者的超敏C-反应蛋白(hs-CRP)、IGF-1、VEGF水平、性激素水平[雌二醇(E_(2))、孕酮(P)、人绒毛膜促性腺激素(HCG)、促黄体生成素(LH)、促卵泡生成激素(FSH)、促黄体生成素/促卵泡生成激素(LH/FSH)]及不良反应发生情况。结果治疗前,两组患者的hs-CRP、IGF-1、VEGF水平比较,差异无统计学意义(P>0.05);治疗后,观察组的hs-CRP、IGF-1、VEGF水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的E_(2)、P、HCG、LH、FSH、LH/FSH水平比较,差异无统计学意义(P>0.05);治疗后,观察组的E_(2)、FSH、P水平高于对照组,HCG、LH、LH/FSH水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的用药不良反应总发生率(5.71%)低于对照组(28.57%),差异有统计学意义(P<0.05)。结论采用亮丙瑞林治疗子宫肌瘤的效果显著,可有效改善血清水平,稳定性激素水平,药物使用安全,值得临床推广应用。
Objective To investigate the influence of Leuprorelin on serum insulin-like growth factor 1(IGF-1),vascular endothelial growth factor(VEGF)and sex hormone levels in patients with uterine fibroids.Methods A total of 70 patients with uterine fibroids treated in Huiyang Sanhe Hospital from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into the observation group(35 cases)and the control group(35 cases).The observation group was treated with Leuprorelin,and the control group was treated with Mifepristone.The levels of hypersensitive C-reactive protein(hs-CRP),IGF-1 and VEGF,the levels of sex hormones(estradiol[E_(2)],progesterone[P],human chorionic gonadotropin[HCG],luteinizing hormone[LH],follicle-stimulating hormone[FSH],luteinizing hormone/follicle-stimulating hormone[LH/FSH])and the incidence of adverse reactions between the two groups were compared.Results Before treatment,there were no significant differences in the levels of hs-CRP,IGF-1,VEGF between the two groups(P>0.05).After treatment,the levels of hs-CRP,IGF-1,VEGF in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistical significance in the levels of E_(2),P,HCG,LH,FSH,LH/FSH between the two groups(P>0.05).After treatment,the levels of E_(2),FSH and P in the observation group were higher than those in the control group,and the levels of HCG,LH and LH/FSH in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the total incidence of adverse drug reactions in the observation group(5.71%)was lower than that in the control group(28.57%),with statistical significance(P<0.05).Conclusion Leuprorelin is effective in the treatment of uterine fibroids,which can effectively improve the serum level,stabilize the level of sex hormone,and the drug is safe.It is worthy of clinical promotion and application.
作者
彭灿
傅春华
欧水英
PENG Can;FU Chun-hua;OU Shui-ying(Department of Gynecology,Huiyang Sanhe Hospital,Guangdong Province,Huizhou,516200,China)
出处
《中国当代医药》
CAS
2021年第33期129-131,135,共4页
China Modern Medicine
