摘要
细胞自噬广泛发生在所有真核细胞的基础生理过程中,是细胞通过降解自身结构或物质从而获得能量的一种自我保护机制。近年来,学者们发现各种组织和细胞在体内受到不同类型的机械应力同样可以通过多种机械转导途径诱导自噬,调控细胞代谢功能,并参与多种疾病的病理过程。细胞膜上的应力感受器以及细胞内的多条信号通路和细胞骨架已被证明在该过程中发挥了重要作用。目前,由于应力加载模型建立的困难以及相关研究手段的局限,机械应力诱导细胞自噬的具体机械转导机制尚不清楚。因此,需要更可靠的体内外模型和更先进的研究方法来了解机械应力诱导自噬的机械转导过程,并最终促进自噬相关疾病及其治疗方法的进展。本文就机械应力在生理及疾病过程中对自噬的调节作用以及机械应力诱导自噬的相关信号转导过程作一综述。
As a self-protective mechanism for cells to obtain energy by degrading their own structures or substances,autophagy widely occurs in basic physiological process of all kinds of eukaryotic cells.In recent years,studies have shown that autophagy can be induced through a variety of mechanical transduction pathways when various tissues and cells are exposed to different types of mechanical stress,and cells and tissues involved can thus regulate cell metabolic functions and participate in the pathological process of a variety of diseases.The stress receptors on the cell membrane and the multiple signaling pathways and cytoskeletons have been shown to play an important role in this process.At present,due to the difficulties in the establishment of the stress loading model and the limitations in the research methods concerned,the specific mechanical transduction mechanisms of autophagy induced by mechanical stress is not clear.Therefore,more reliable in vitro and in vivo models and more advanced research methodology are needed to investigate the mechanical transduction process of autophagy induced by mechanical stress,and to promote ultimately progress in the understanding of autophagy-related diseases and their treatments.This article reviewed the regulatory role of mechanical stress on autophagy in physiological and disease processes and the signal transduction process related to autophagy induced by mechanical stress.
作者
蒋玉坤
胡芝爱
关禹哲
周陈晨
邹淑娟
JIANG Yu-kun;HU Zhi-ai;GUAN Yu-zhe;ZHOU Chen-chen;ZOU Shu-juan(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,and Department of Orthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2021年第6期929-935,共7页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.82071150)资助。
关键词
自噬
应力
机械转导
Autophagy
Mechanical stress
Mechanotransduction
