摘要
目的探讨骨水泥填充对晚期肿瘤骨转移痛患者的治疗效果。方法回顾性分析贵州省骨科医院疼痛科2010年1月至2019年12月收治的晚期肿瘤骨转移患者74例,病理诊断分别为多发性骨髓瘤33例,乳腺癌12例,前列腺癌9例,肺癌16例,宫颈癌1例,卵巢癌1例,肾癌1例,胸腺癌1例。通过经皮穿刺骨水泥填充骨转移病灶治疗,于术前,术后1 d、1个月时记录患者视觉模拟评分(VAS)、Karnofsky Performance Status(KPS)评分及Kessler 10量表(K10)评分,记录术前及术后1个月使用镇痛药物的患者例数,并分析临床疗效。结果术后1 d和1个月时VAS评分分别为(1.6±0.9)分、(1.7±0.8)分,均较治疗前(6.1±1.3)分降低,且差异有统计学意义(P<0.001)。术后1 d和1个月时KPS评分分别为(58±9)分和(55±8)分,均较治疗前的(40±8)分升高,差异有统计学意义(P<0.001)。术后1 d和1个月时K10评分分别为(22±6)分和(23±6)分,均较术前(33±8)分降低,差异有统计学意义(P<0.001);术前需要使用镇痛药物患者63例,术后1个月随访时为20例(P<0.001)。结论骨水泥填充可以有效缓解晚期肿瘤骨转移患者疼痛程度,改善其活动度,并提高生活质量。
Objective To investigate the efficacy of bone cementoplasty in bone metastases of advanced tumor.Methods Retrospective analysis of 74 patients with bone metastases of advanced tumor treated by bone cementoplasty was in the Department of Pain Medicine of Guizhou Orthopedic Hospital from January 2010 to December 2019.The pathological diagnosis was multiple myeloma 33 cases,breast cancer 12 cases,prostate cancer 9 cases,lung cancer 16 cases,cervical cancer 1 case,ovarian cancer 1 case,renal cancer 1 case,thymus cancer 1 case.The VAS,Karnofsky performance status(KPS)score and Kessler 10 scale(K10)were recorded before and one day,one month after the treatment.The patients using analgesics before and one month after the treatment were recorded.Results VAS was(1.6±0.9)score and(1.7±0.8)score at one day and one month after the treatment,which were decreased,compared with that before the operation(6.1±1.3),with significant difference(P<0.001).Compared with preoperation(40±8),KPS score was(58±9)at one day and(55±8)at one1 month after the treatment(P<0.001).The K10 score decreased from preoperation(33±8)at one day(22±6)and(23±6)at one month after the treatment(P<0.001).Only 20 patients still took analgesics at one month after the treatment(P<0.001).Conclusion Bone cementoplasty can effectively relieve pain,improve activity and quality of life in the advanced tumor patients with bone metastases.
作者
钱黎
陈黔
潘奇
王大寿
简乾洪
Qian Li;Chen Qian;Pan Qi;Wang Dashou;Jian Qianhong(Department of Pain Medicine,Orthopedic Hospital of Guizhou Province,Guiyang City,Guizhou Province 550002,China)
出处
《中华疼痛学杂志》
2021年第5期484-490,共7页
Chinese Journal Of Painology
关键词
肿瘤
晚期
骨肿瘤
转移
疼痛
骨水泥成形
Neoplasms,advanced-stage
Bone neoplasms
Metastasis
Pain
Bone cementoplasty
