摘要
1例25岁男性患者自行服用苯巴比妥东莨菪碱约60片(每片含苯巴比妥30 mg和氢溴酸东莨菪碱0.2 mg),约1 h后出现昏迷伴四肢阵发性抽搐。诊断为药物中毒,予洗胃、导泻,以及咪达唑仑10 mg静脉注射抗癫痫等治疗。6 h后患者心率53次/min,呼吸11次/min,偶发抽搐,并出现血尿。实验室检查示间接胆红素16.97μmol/L、总蛋白54 g/L,白蛋白27.6 g/L、凝血酶时间25.0 s,考虑多脏器损伤。给予血液净化治疗。1 d后患者神志转清,心率68次/min,呼吸16次/min,未再出现抽搐;2 d后,实验室检查示间接胆红素8.69μmol/L,总蛋白54.7 g/L,白蛋白34.0 g/L,凝血酶时间16.7 s。
A 25‑year‑old male patient took about 60 tablets of phenobarbital and scopolamine hydrobromide by himself(each tablet contains 30 mg phenobarbital and 0.2 mg scopolamine hydrobromide).About 1 hour later,he developed coma with paroxysmal limb convulsions.Drug poisoning was diagnosed.The patient received gastric lavage,catharsis,and intravenous injection of midazolam 10 mg for epilepsy.Six hours later,his heart rate was 53 beats/min,breathing rate was 11 times/min,and occasional convulsions and hematuria occurred.Laboratory tests showed indirect bilirubin 16.97μmol/L,total protein 54 g/L,albumin 27.6 g/L,and thrombin time 25.0 s.Multiple organ injury was considered and blood purification treatment was given.One day later,the patient′s consciousness was restored,heart rate was 68 beats/min,breathing rate was 16 times/min,and no convulsion occurred.Laboratory tests showed indirect bilirubin 8.69μmol/L,total protein 54.7 g/L,albumin 34.0 g/L,and thrombin time 16.7 s.
作者
孙博
刘勋
张二锋
马换青
Sun Bo;Liu Xun;Zhang Erfeng;Ma Huanqing(Department of Pharmacy,the Third People′s Hospital of Zhengzhou,Zhengzhou 450099,China;Department of Pharmacy,Zhengzhou Second Hospital,Zhengzhou 450006,China)
出处
《药物不良反应杂志》
CSCD
2021年第11期612-614,共3页
Adverse Drug Reactions Journal
关键词
苯巴比妥
东莨菪碱
药物过量
中毒
抽搐
Phenobarbital
Scopolamine
Drug overdose
Poisoning
Tetany
