摘要
原发性醛固酮增多症(primary aldosteronism,PA)是继发性高血压的常见病因之一,部分PA是由肾上腺皮质腺瘤导致的。肾上腺皮质腺瘤常规的治疗方法是单侧肾上腺切除术,术后多数患者高血压、低血钾等症状得以改善,但有少部分会出现肌酐升高、估算肾小球滤过率(estimated glomerular filtration rate,eGFR)降低。本文就1例醛固酮腺瘤患者术后出现eGFR下降进行讨论,以期为临床治疗提供参考。
We report one case of estimated glomerular filtration rate(eGFR)decline after taking unilateral adrenalectomy due to aldosterone adenoma.A 60-year-old male with 23-year history of hypertension was reported to the endocrinologist due to hypokalemia(serum potassium 3.01 mmol/L).Urine microalbumin/creatinine(ALB/CR)was 70.15 mg/g,serum creatinine was 82μmol/L and eGFR was 89.79 mL/(min·1.73 m2).Random serum aldosterone was 172.2-203.5 ng/L,and random plasma rennin activity was 0-0.17μg/(L·h).His captopril challenge test suggested that his aldosterone le-vels were suppressed by 8%(<30%)and the adrenal enhanced computed tomography scan revealed a left adrenal tumor.The patient was diagnosed with primary hyperaldosteronism(PA),aldosterone adenoma and underwent left laparoscopic adrenalectomy.Histological examination confirmed adrenal cortical adenoma.One week after the operation,his serum creatinine was increased to 127μmol/L compared with preoperative level;eGFR was 32.34 mL/(min·1.73 m2).His systolic blood pressure(SBP)was 110 mmHg and diastolic blood pressure(DBP)was 60 mmHg(hypotensive drugs discontinued),and serum potassium level was 5.22 mmol/L.At the end of the 2-year follow up,the serum creatinine of this patient remained at 109-158μmol/L and eGFR fluctuated from 63.28-40.12 mL/(min·1.73 m2).PA is one of the most common causes of secondary hypertension.Several studies have reported renal function deterioration of PA patients after unilateral adrenalectomy,like the patient in this article.Age,preoperative plasma aldosterone concentration,albuminuria and preoperative potassium level might be significant predictors of a decrease in the eGFR.Growing evidence suggests that aldosterone could contribute to structural kidney damage,arterial injury and hemodynamic disorder.At the same time,patients with PA exhibit glomerular hyperfiltration and glomerular vascular hypertension,leading to the misinterpretation of renal function in PA patients as subtle kidney damage may be masked by the glomerular hyperfiltration before treatment.After a unilateral adrenalectomy,glomerular hyperfiltration by aldosterone excess is resolved and renal damage can be unmasked.In conclusion,kidney function deterioration after adrenalectomy can be detected in some patients with PA.Thus,accurate evaluation of kidney function in patients with PA may be essential,especially for those with preoperative risk factors for postoperative renal impairment.After unilateral adrenalectomy,close monitoring of renal function and adequate management are required for PA patients.
作者
安文成
闫慧娴
邓正照
陈芳
欧小虹
金红心
黄薇
AN Wen-cheng;YAN Hui-xian;DENG Zheng-zhao;CHEN Fang;OU Xiao-hong;JIN Hong-xin;HUANG Wei(Department of Endocrinology,Beijing Haidian Hospital,Peking University Third Hospital(Haidian District),Beijing 100080,China;Department of Endocrinology,Peking University Third Hospital,Beijing 100191,China)
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2021年第6期1201-1204,共4页
Journal of Peking University:Health Sciences
