摘要
目的:研究三阴性乳腺癌(TNBC)早期患者雄激素受体(AR)、Ki67、p53、表皮生长因子受体(EGFR)表达水平及其与临床病理特征的关系。方法:选取经临床病理诊断确诊的TNBC早期患者80例作为TNBC组,同时选取非三阴性乳腺癌(NTNBC)早期患者80例作为NTNBC组。应用免疫组化方法检测两组患者AR、Ki67、p53、EGFR表达水平并进行比较。分析各指标表达情况与TNBC早期患者临床病理特征之间的关系。结果:TNBC组患者AR阳性表达率显著低于NTNBC组,Ki67、p53及EGFR阳性表达率显著高于NTNBC组(均P<0.05)。TNBC患者中,AR阳性表达患者中出现淋巴结转移的患者比例更低,Ki67阳性表达患者中组织学分级Ⅱ期的患者比例更高,p53阳性表达患者中出现脉管内浸润的比例更高,EGFR阳性表达患者中肿瘤直径≥2 cm和出现脉管内浸润的患者比例更高(均P<0.05)。结论:TNBC早期患者AR表达降低,Ki67、p53、EGFR表达增加,且各指标与TNBC早期患者临床病理特征间均存在一定相关关系。
Objective:To study the expression levels of androgen receptor(AR),Ki67,p53 and epidermal growth factor receptor(EGFR)and their relationship with clinicopathological characteristics in early stage triple-negative breast cancer(TNBC)patients.Methods:A total of 80 early TNBC patients diagnosed by clinical pathology were selected as the TNBC group,and 80 early patients with non-triple negative breast cancer(NTNBC)were selected as the NTNBC group.The expression levels of AR,Ki67,p53 and EGFR in the two groups were detected by immunohistochemical methods and compared.The relationship between the expression of above indicators and the clinicopathological characteristics of early TNBC patients was analyzed.Results:The positive expression rate of AR in the TNBC group was significantly lower than that in the NTNBC group,and the positive expression rates of Ki67,p53 and EGFR were significantly higher than those in the NTNBC group(all P<0.05).Among TNBC patients,the proportion of patients with lymph node metastasis in AR-positive patients was lower,the proportion of patients with histological gradeⅡwas higher in Ki67-positive patients,and the proportion of patients with p53-positive expression was higher in intravascular infiltration,and the proportion of patients with tumor diameter≥2 cm and intravascular infiltration were higher in EGFR-positive patients(all P<0.05).Conclusion:The expression of AR in early TNBC patients decreases,and the expression of Ki67,p53,and EGFR increase.There is a certain correlation between each indicators and the clinicopathological characteristics of early TNBC patients.
作者
徐英杰
李巍
XU Yingjie;LI Wei(Jinzhou Medical University,Jinzhou 121001,China)
出处
《陕西医学杂志》
CAS
2021年第12期1594-1597,共4页
Shaanxi Medical Journal
基金
辽宁省锦州市指导性科技计划项目(JZ2020B017)。
关键词
三阴性乳腺癌
雄激素受体
KI67
表皮生长因子受体
临床病理特征
Triple-negative breast cancer
Androgen receptor
Ki67
Epidermal growth factor receptor
Clinicopathological characteristics
