摘要
目的:观察不同证型膝骨关节炎Ⅰ型胶原蛋白C末端异物肽(CTX-Ⅰ)、抗酒石酸酸性磷酸酶(TRACP)、聚蛋白多糖酶-4(ADAMTS-4)和基质金属蛋白酶-3(MMPs-3)的表达及相关性。方法:从武汉市蔡甸区人民医院康复疼痛科、风湿科纳入98例诊断为膝骨关节炎的患者,根据患者证型分为阳虚寒凝型40例,气滞血瘀型28例,肾精亏虚型30例。比较不同证型的CTX-Ⅰ、TRACP、ADAMTS-4、MMPs-3水平差异以及CTX-Ⅰ、TRACP水平与ADAMTS-4、MMPs-3水平的相关性。结果:3组不同证型CTX-Ⅰ、TRACP、ADAMTS-4、MMPs-3含量比较,差异有统计学意义(P<0.05);阳虚寒凝证与CTX-Ⅰ、TRACP、ADAMTS-4、MMPs-3水平均呈正相关(P<0.05);气滞血瘀证与TRACP、ADAMTS-4水平呈正相关,与MMPs-3水平呈负相关(P<0.05);肾精亏虚证与CTX-Ⅰ、ADAMTS-4、MMPs-3水平呈现正相关(P<0.05);骨代谢指标(CTX-Ⅰ、TRACP)水平与ADAMTS-4、MMPs-3水平呈正相关(P<0.05)。结论:不同证型膝骨关节炎与CTX-Ⅰ、TRACP、ADAMTS-4、MMPs-3存在相关性,能为临床中医辨证分型提供一定的客观依据。
Objective:To observe the expression ofⅠcollagen C-terminal foreign body peptide(CTX-Ⅰ)and tartrate-resistant acid phosphatase(TRACP),polyproteoglycan enzyme-4(ADAMTS-4)and matrix metalloproteinase-3(MMPs-3)in different syndromes of knee osteoarthritis and their correlation.Methods:A total of 98 patients diagnosed with knee osteoarthritis were enrolled from the Rehabilitation Pain Department and Rheumatology Department of Wuhan Caidian District People's Hospital.According to their syndrome types,they were divided into 40 cases of the Yang deficiency and cold constipation type,28 cases of the qi stagnation and blood stasis type,and 30 cases of the kidney essence deficiency type.The difference of CTX-Ⅰ,TRACP,ADAMTS-4 and MMPs-3 in different syndromes was compared.Correlation of CTX-Ⅰ,TRACP,ADAMTS-4 and MMPs-3 with different sydromes was determined.Results:There were statistically significant differences in the contents of CTX-Ⅰ,TRACP,ADAMTS-4 and MMPs-3 among the three syndromes(P<0.05).There was a positive correlation between the Yang deficiency and cold constipation type and CTX-Ⅰ,TRACP,ADAMTS-4,MMPs-3(P<0.05).The syndrome of qi stagnation and blood stasis was positively correlated with TRACP and ADAMTS-4,and negatively correlated with MMPs-3(P<0.05).The renal essence deficiency syndrome was positively correlated with CTX-Ⅰ,ADAMTS-4 and MMPs-3(P<0.05).Bone metabolic indexes(CTX-Ⅰ,TRACP)were positively correlated with ADAMTS-4 and MMPs-3(P<0.05).Conclusion:Different syndromes of knee osteoarthritis are correlated with bone metabolism indexes,ADAMTS-4 and MMPs-3,which can provide references for clinical TCM syndrome differentiation and classification.
作者
江润
张涛
段骏
毛珍
JIANG Run;ZHANG Tao;DUAN Jun;MAO Zhen(Department of Rheumatology,Wuhan Caidian District People's Hospital,Wuhan 430000,China;Department of Rehabilitation Pain,Wuhan Caidian District People's Hospital,Wuhan 430000,China)
出处
《海南医学院学报》
CAS
2021年第23期1781-1785,共5页
Journal of Hainan Medical University
基金
武汉市卫生计生委科研计划资助项目(WZ20Q12)
国家自然科学基金重大项目(81590955)。
