摘要
目的比较纳布啡与地佐辛用于可视无痛人工流产术的效果及安全性。方法选取中山市人民医院、中山市沙溪隆都医院2020年1-9月行无痛人工流产术的患者120例为研究对象,采用随机数字表法分为纳布啡组(N组)、地佐辛组(D组),每组60例。分别静脉给予盐酸纳布啡注射液0.15 mg/kg(N组)、地佐辛注射液5 mg(D组),随后静脉注射丙泊酚2 mg/kg,待睫毛反射消失后进行手术操作,如有体动,酌情追加30~50 mg的丙泊酚。比较两组麻醉前(T0)、手术开始3 min(T1)、苏醒时(T2)收缩压(SBP)、舒张压(DBP)、血氧饱和度(SpO_(2))、心率(HR)的变化,术后苏醒时间、术后视觉模拟疼痛(VAS)评分、丙泊酚用量、手术时间、不良反应发生的情况。结果两组在T0、T1、T2时的SBP、HR等均有变化,但差异均无统计学意义(均P>0.05);两组苏醒时间、术后VAS评分、丙泊酚用量、手术时间差异均无统计学意义(均P>0.05);N组恶心、眩晕发生率分别为8.3%(5/60)、11.6%(7/60),均低于D组的30.0%(18/60)、31.6%(19/60),差异均有统计学意义(χ^(2)=9.09、7.07,均P<0.05)。结论纳布啡联合丙泊酚用于无痛人工流产术具有良好的麻醉效果及安全性,术中及术后不良反应少,优于地佐辛联合丙泊酚麻醉。
Objective To investigate the efficacy and safety of naborphine versus dezocine in painless visual anesthetics induced abortion.Methods A total of 120 patients who underwent painless visual anesthetics induced abortion in Zhongshan City People's Hospital and Zhongshan Shaxi Longdu Hospital,China during January to September in 2020.They were randomly assigned to receive intravenous naborphine hydrochloride injection(0.15 mg/kg,naborphine group)or dezocine injection(5 mg,dezocine group),followed by intravenous propofol(2 mg/kg).When the eyelash reflex disappeared,surgery was initiated.If there were body movements,30-50 mg propofol was added as appropriate.Systolic blood pressure,diastolic blood pressure,blood oxygen saturation,and heart rate before anesthesia(T0),at 3 minutes after the beginning of surgery(T1),and during recovery(T2)were compared between the two groups.The time to regain consciousness,postoperative visual analogue pain score,propofol dose,operative time,and adverse reactions were determined in each group.Results There were slight,but not significant,differences in systolic blood pressure and heart rate between the two groups at T0,T1 and T2(all P>0.05).There were no significant differences in time to regain consciousness,postoperative visual analogue pain score,propofol dose and operative time between the two groups(all P>0.05).The incidence of nausea and vertigo in the naborphine group was 8.3%(5/60)and 11.6%(7/60),respectively,which was significantly lower than that in the dezocine group[30.0%(18/60),31.6%(19/60),χ^(2)=9.09,7.07,both P<0.05).Conclusion Naborphine combined with propofol for painless visual anesthetics induced abortion exhibits good anesthetic effects and safety,with fewer intraoperative and postoperative adverse reactions than dezocine combined with propofol.
作者
秦莹
高满意
郭慧仪
Qin Ying;Gao Manyi;Guo Huiyi(First Department of Surgical Anesthesia,Zhongshan City People's Hospital,Zhongshan 528400,Guangdong Province,China;Department of Surgical Anesthesia,Zhongshan Shaxi Longdu Hospital,Zhongshan 528400,Guangdong Province,China)
出处
《中国基层医药》
CAS
2021年第12期1835-1838,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
流产
人工
超声检查
纳布啡
地佐辛
丙泊酚
麻醉
静脉
疼痛
手术后
手术后恶心呕吐
Abortion,induced
Ultrasonography
Nalbuphine
Dezocine
Propofol
Anesthesia,intravenous
Pain,postoperative
Postoperative nausea and vomiting
