摘要
随着人工关节置换手术总数的不断增长,术后假体周围感染(periprosthetic joint infection,PJI)的绝对数量也在增加。人工全膝关节置换(total knee arthroplasty,TKA)和人工全髋关节置换(total hip arthroplasty,THA)术后假体周围感染的治疗目前仍具有挑战性。在现有的几种治疗方案中,一期植入抗生素负载的骨水泥间隔物,二期再行假体植入被认为是治疗PJI的金标准[1]。但因其治疗周期长,且需要行多次手术,使得相当一部分的患者在植入间隔物后未再行二期手术植入新的假体。随着间隔物制作技术的成熟,已经有越来越多的学者报道了保留抗生素骨水泥间隔物治疗PJI取得了较为满意的临床疗效。本文综述了抗生素骨水泥间隔物的材料特性、保留间隔物的临床应用现状,归纳总结了临床疗效,分析了目前其优势及缺点,并对未来的发展做了展望。
However, due to the long treatment cycle and the need for multiple operations, a considerable number of patients do not undergo the second operation to implant a new prosthesis after the spacers implantation. With the development of spacers fabrication technology, more and more scholars have reported that reserved antibiotic bone cement spacers have achieved satisfactory clinical efficacy in the treatment of PJI.
作者
张效溥
向川
ZHANG Xiaopu;XIANG Chuan(Department of Joint Surgery,Second Affiliated Hospital of Shanxi Medical University,Taiyuan 030001)
出处
《北京生物医学工程》
2021年第6期635-641,共7页
Beijing Biomedical Engineering
基金
国家自然科学基金(81972075)资助。
关键词
间隔物
假体周围感染
全髋关节置换
全膝关节置换
抗生素骨水泥
spacers
periprosthetic joint infection
total knee arthroplasty
total hip arthroplasty
antibiotic-loaded bone cement
