摘要
目的论甲基强的松龙短程注射联合不同糖皮质激素(甲基泼尼松龙和强的松)长期口服用药治疗重症肌无力的效果。方法选取2019年1月-2020年1月该院收治的82例重症肌无力患者作为研究对象,以随机(抽签法)方法分为观察组(n=41)和对照组(n=41)。两组患者均短程注射用药甲基强的松龙,分别在此基础上为两组患者用药甲基泼尼松龙(观察组)和强的松(对照组),对治疗的总有效率、不良反应发生率、治疗前后的血清白细胞介素-6、血清白细胞介素-10和血清乙酰胆碱受体滴度进行比较。结果①观察组的治疗总有效率(92.68%)和对照组(90.24%)比较,差异无统计学意义(P>0.05)。②观察组的用药不良反应发生率(9.76%)明显低于对照组(29.27%),差异有统计学意义(P<0.05)。③治疗前,两组患者血清白细胞介素-6、血清白细胞介素-10和血清乙酰胆碱受体滴度水平比较,差异无统计学意义(t=0.102、0.329、0.274,P>0.05);治疗后,各项指标水平都大大减轻,但两组比较差异无统计学意义(t=0.023、0.061、0.376,P>0.05)。结论通过糖皮质激素甲基强的松龙短程注射联合甲基泼尼松龙长期口服用药治疗重症肌无力的效果和强的松长期口服治疗之间无明显差异,对改善患者相关指标方面也无明显差异,但是用药的安全性比强的松更好,特别是减轻了对患者肝脏的损伤,是理想的联合用药。
Objective To discuss the effect of short-term injection of methylprednisolone combined with different glucocorticoids(methylprednisolone and prednisone)for long-term oral medication in the treatment of myasthenia gravis.Methods 82 patients with myasthenia gravis treated in the hospital from January 2019 to January 2020 were randomly divided into observation group(n=41)and control group(n=41).Both groups of patients were given short-term injections of methylprednisolone,and on this basis,the two groups of patients were treated with methylprednisolone(observation group)and prednisone(control group).The total effective rate of treatment,incidence of adverse reactions,serum interleukin-6,serum interleukin-10 and serum acetylcholine receptor titers before and after treatment were compared.Results 1.There was no statistically significant difference in the total effective rate between the observation group(92.68%)and the control group(90.24%)(P>0.05).2.The incidence of adverse drug reactions in the observation group(9.76%)was significantly lower than that in the control group(29.27%),and the difference was statistically significant(P<0.05).3.Before treatment,there was no statistically significant difference in serum interleukin-6,serum interleukin-10 and serum acetylcholine receptor titer between the two groups(t=0.102,0.329,0.274,P>0.05);after treatment,the levels of various indexes were greatly reduced,but there was no statistically significant difference between the two groups(t=0.023,0.061,0.376,P>0.05).Conclusion There is no significant difference between the effect of short-term injection of the glucocorticoid methylprednisolone combined with long-term oral medication of methylprednisolone in the treatment of myasthenia gravis and the long-term oral treatment of prednisone,and there is no significant difference in the improvement of related indicators in patients.However,the safety of the medication is better than that of prednisone,especially it reduces the damage to the patient's liver.It is an ideal combination medication.
作者
钱显光
QIAN Xianguang(Emergency Department,Xishuangbanna Prefecture People's Hospital,Xishuangbanna,Yunnan Province,661000 China)
出处
《系统医学》
2021年第19期57-60,共4页
Systems Medicine
