摘要
目的探索胸腔镜下肺癌根治术治疗老年非小细胞肺癌(NSCLC)的疗效及患者生存率。方法120例老年NSCLC患者,以简单随机化法分为对照组与实验组,各60例。对照组选择传统开胸NSCLC根治术,实验组选择胸腔镜下肺癌根治术。比较两组手术情况指标、肺功能指标、实验室指标、术后1年生存率。结果实验组手术时间及淋巴结清扫数目与对照组比较,差异无统计学意义(P>0.05);实验组术中出血量(170.50±37.40)ml少于对照组的(289.15±37.50)ml,住院时间(12.20±2.50)d短于对照组的(16.00±3.65)d,视觉模拟评分法(VAS)评分(4.35±1.30)分低于对照组的(6.75±1.85)分,差异均有统计学意义(P<0.05)。术后1个月,两组的肺活量(VC)、第1秒用力呼气容积(FEV1)及每分钟最大通气量(MVV)均高于本组术前1 d,且实验组高于对照组,差异有统计学意义(P<0.05)。术后1个月,两组的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)及免疫球蛋白G(IgG)均高于本组术前1 d,且实验组均高于对照组,差异有统计学意义(P<0.05)。实验组的术后1年生存率73.33%高于对照组的55.00%,差异有统计学意义(P<0.05)。结论老年NSCLC患者应用胸腔镜下肺癌根治术能改善肺功能指标及手术情况指标,且术后实验室指标更高,术后1年生存率高。
Objective To discuss the efficacy and survival rate of thoracoscopic radical resection of lung cancer in elderly patients with non-small cell lung cancer(NSCLC).Methods A total of 120 elderly patients with NSCLC were divided into the control group and the experimental group by a simple randomization method,with 60 cases in each group.The control group was treated with traditional thoracotomy,and the experimental group was treated with thoracoscopic radical resection of lung cancer.The surgical indicators,pulmonary function indicators,laboratory indicators,and 1-year survival rate were compared between the two groups.Results Compared with the control group,the operation time and number of lymph node dissection in the experimental group were not statistically different(P>0.05).The intraoperative blood loss(170.50±37.40)ml of the experimental group was less than(289.15±37.50)ml of the control group,the hospitalization time(12.20±2.50)d was shorter than(16.00±3.65)d of the control group,and the visual analogue scale(VAS)score(4.35±1.30)points was lower than(6.75±1.85)points of the control group.All the differences were statistically significant(P<0.05).1 month after surgery,the vital capacity(VC),forced expiratory volume in the 1st second(FEV1)and maximal voluntary ventilation(MVV)of the two groups were higher than those of this group 1 d before surgery,and the experimental group was higher than the control group.All the differences were statistically significant(P<0.05).1 month after surgery,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)in the two groups were higher than those in this group 1 d before surgery,and the experimental group was higher than the control group.All the differences were statistically significant(P<0.05).The 1-year survival rate 73.33%of the experimental group was higher than 55.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion Thoracoscopic radical resection of lung cancer in elderly patients with NSCLC can improve the pulmonary function indicators and the surgical-related indicators,and has higher laboratory indicators and 1-year survival rate.
作者
马东晖
MA Dong-hui(Department of Thoracic Surgery,Dalian Friendship Hospital,Dalian 116000,China)
出处
《中国现代药物应用》
2021年第22期44-47,共4页
Chinese Journal of Modern Drug Application
关键词
老年
非小细胞肺癌
胸腔镜下肺癌根治术
疗效
生存率
Elderly patients
Non-small cell lung cancer
Thoracoscopy radical resection of lung cancer
Efficacy
Survival rate
