摘要
辐射旁效应(radiation-induced bystander effects,RIBE)是指受辐射的细胞通过一定的机制将损伤效应传递给未受辐射的细胞,未受辐射的细胞表现出类似于受辐射细胞的生物损伤效应现象。近年发现,多类调控蛋白及信号通路在重离子辐射旁效应过程中参与细胞凋亡、细胞增殖、细胞周期阻滞等生物学效应。本文就这些调控蛋白及信号通路在重离子辐射旁效应中的作用机制作一综述。
Radiation-induced bystander effects(RIBE)means that radiated cells transmit the damage effect to the irradiated cells through a certain mechanism and irradiated cells show similar biological damage effects to radiated cells. In recent years,many kinds of regulatory proteins and signaling pathways have been found to be involved in apoptosis,proliferation,cell cycle arrest and other biological effects in the process of heavy ion RIBE. This article reviewed the mechanism of these regulatory proteins and signaling pathways in heavy ion RIBE.
作者
石国秀
颜春鲁
安方玉
汪永锋
张艳霞
赵磊
赵崇博
成新平
靳安顺
Shi Guoxiu;Yan Chunlu;An Fangyu;Wang Yongfeng;Zhang Yanxia;Zhao Lei;Zhao Chongbo;Cheng Xinping;Jin Anshun(School of Public Health,Gansu University of traditional Chinese Medicine/Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education/Key Laboratory of Chemistry and Quality for Chinese(Tibetan)Medicine Research of Universities of Gansu Province)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2021年第10期1270-1275,共6页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81760797)
甘肃省高校大学生就业创业能力提升工程资助项目(编号:6-1)
敦煌医学与转化省部共建教育部重点实验室开放基金资助项目(编号:DHYX18-15)。
关键词
重离子辐射
旁效应
调控蛋白
信号通路
heavy ion radiation
bystander effects
regulating proteins
signaling pathways
