摘要
银屑病是一种慢性炎症性皮肤病,严重影响患者的生活质量。糖皮质激素是临床治疗银屑病的一线用药,但长期应用易出现病情反复、加重等。而糖皮质激素受体及其相关信号通路在银屑病的发病过程以及激素抵抗方面均具有重要作用。银屑病患者角质形成细胞中的糖皮质激素受体表达水平显著低于健康人,同时糖皮质激素受体还参与银屑病的神经免疫调节并发挥重要作用。因此,未来可从糖皮质激素受体与神经免疫调节等方面研究其在银屑病发病机制中的作用,从而为银屑病的治疗提供依据。
Psoriasis is a chronic inflammatory skin disease that seriously affects the quality of life of patients.Glucocorticoids are the first-line drugs for the clinical treatment of psoriasis,but relapse and aggravation may often occur after long-term use.Glucocorticoid receptors and related signaling pathways play an important role in the pathogenesis of psoriasis and hormone resistance.The expression level of glucocorticoid receptor in the keratinocytes of the patients with psoriasis is significantly lower than that of healthy people.At the same time,the glucocorticoid receptor also participates in the neuroimmune regulation of psoriasis and plays an important role.Therefore,in the future,the role of glucocorticoid receptors and neuroimmune regulation in the pathogenesis of psoriasis can be studied to provide references for the treatment of psoriasis.
作者
杨春梅
蒯仂
茹意
罗楹
邢梦
丁晓杰
叶晖
蒋建明
李欣
李斌
YANG Chunmei;KUAI Le;RU Yi;LUO Ying;XING Meng;DING Xiaojie;YE Hui;JIANG Jianming;LI Xin;LI Bin(Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Institute of Dermatology,Shanghai Academy of Traditional Chinese Medicine,Shanghai 201203,China;Department of Stomatology,Shanghai Changhai Hospital,Shanghai 200433,China;Department of Neurology,Shanghai Changhai Hospital,Shanghai 200433,China)
出处
《医学综述》
CAS
2021年第23期4598-4603,共6页
Medical Recapitulate
基金
国家自然科学基金(81874470,81973860,81904214,82074427)
国家重点研发计划(2018YFC1705301)
上海市进一步加快中医药事业发展三年行动计划(2018年—2020年)[ZY(2018-2020)-FWTX-1008,ZY(2018-2020)-FWTX-4010]
上海领先人才计划项目(039)
上海市浦江人才计划(2020PJD067)
上海中医药大学杏林青年学者(RY411.33.10)。
