摘要
目的探讨糖类抗原125(CAl25)、D-二聚体(D-D)、糖类抗原19-9(CAl99)联合检测诊断卵巢癌的价值。方法选择2018年10月—2020年1月本院收治的103例卵巢肿瘤患者作为研究对象,根据病理学诊断结果将其分为卵巢癌组(40例)与卵巢良性肿瘤组(63例)两组。两组受检者均行CA125、D-D及CA19-9检测。对比两组患者的血清CA125、D-D及CA19-9水平;比较血清CA125、D-D、CA19-9及三项肿瘤标志物联合检测的阳性率;比较不同临床分期卵巢癌患者的血清CA125、D-D及CA19-9水平。结果卵巢癌组CA125、D-D及CA19-9水平高于卵巢良性肿瘤组,差异具有统计学意义(P<0.01)。卵巢癌组CA125、D-D、CA19-9及三项肿瘤标志物联合检测的阳性率高于卵巢良性肿瘤组,差异具有统计学意义(P<0.01)。卵巢癌Ⅲ-Ⅳ期组CA125、D-D及CA19-9水平高于卵巢癌Ⅰ-Ⅱ期组,差异具有统计学意义(P<0.01)。结论CA125、D-D及CA19-9联合检测在卵巢癌患者中具有显著的应用效果,为临床诊疗提供了较为可靠的参考依据。
Objective To investigate the clinical effect of combined detection of carbohyrate antigen 125(CAl25),D-Dimer(D-D)and carbohydrate antigen 19-9(CA19-9)in ovarian cancer.Methods 103 patients with ovarian tumors treated in our hospital from October 2018 to January 2020 were selected as the research objects.According to the pathological diagnosis results,they were divided into ovarian cancer group(40 cases)and benign ovarian tumor group(63 cases).CA125,D-D and CA19-9 were detected in both groups.The levels of serum CA125,D-D and CA19-9 were compared between the two groups;The positive rates of serum CA125,D-D,CA19-9 and three tumor markers were compared;The levels of serum CA125,D-D and CA19-9 in patients with ovarian cancer at different clinical stages were compared.Results The levels of CA125,D-D and CA19-9 in ovarian cancer group were significantly higher than those in benign ovarian tumor group(P<0.01).The positive rates of CA125,D-D,CA19-9 and three tumor markers in ovarian cancer group were significantly higher than those in benign ovarian tumor group(P<0.01).The levels of CA125,D-D and CA19-9 in stageⅢ-Ⅳgroup were significantly higher than those in stageⅠ-Ⅱgroup(P<0.01).Conclusions The combined detection of CA125,D-D and CA19-9 has a significant application effect in patients with ovarian cancer,and provides a more reliable reference basis for clinical diagnosis and treatment.
作者
沈晓苗
何志坚
李晓玲
杨嘉丽
Shen Xiaomiao;He Zhijian;Li Xiaoling;Yang Jiali(Department of obstetrics and gynecology,the second affiliated hospital of Guangdong Medical University,Zhanjiang,Guangdong,524003,China)
出处
《齐齐哈尔医学院学报》
2021年第20期1773-1775,共3页
Journal of Qiqihar Medical University
