摘要
目的分析尿肝型脂肪酸结合蛋白(L-FABP)对新生儿窒息后急性肾损伤的临床价值。方法选取2019年9月至2020年12月本院收治的窒息新生儿118例纳入研究组,其中轻度窒息79例,重度窒息39例,新生儿窒息后急性肾损伤48例,非新生儿窒息后急性肾损伤70例,新生儿窒息后急性肾损伤患儿根据急性肾损伤分期标准分为Ⅰ期23例,Ⅱ期14例,Ⅲ期11例。另选择同期健康新生儿118例作为对照组并回顾性收集其临床资料。比较两组的不同窒息程度、新生儿窒息后急性肾损伤及非新生儿窒息后急性肾损伤、不同急性肾损伤分级患儿LFABP、血肌酐(Ser)及血尿素氮(BUN)水平差异,分析L-FABP与Ser及BUN的相关性。结果研究组的L-FABP、Scr及BUN水平均高于对照组(P<0.05)。重度窒息患儿的LFABP、Scr及BUN水平均高于轻度窒息患儿(P<0.05)。新生儿窒息后急性肾损伤患儿的L-FABP、Ser及BUN水平均高于非新生儿窒息后急性肾损伤患儿(P<0.05)。Ⅰ、Ⅱ、Ⅲ期新生儿窒息后急性.肾损伤患儿的L-FABP、Scr及BUN水平呈升高趋势,各组比较差异均有统计学意义(P<0.05)。新生儿窒息后急性肾损伤患儿的L-FABP水平均与Scr、BUN水平呈正相关(r=0.632,P=0.004;r=0.725,P=0.008)。结论LFABP、Ser、BUN在新生儿窒息后急性肾损伤患儿中表达增加,L-FABP与肾功能指标Ser、BUN呈正相关,且其水平随窒息程度、肾损伤程度增加而增加。
Objective To analyze the clinical value of urinary liver-fatty acid binding protein(L-FABP)in the treatment of acute renal injury after neonatal asphyxia.Methods From September 2019 to December 2020,118 asphyxiated newborn infants in our hospital were included in the study group.There were 79 cases of mild asphyxia,39 eases of severe asphyxia,48 cases of acute kidney injury after neonatal asphyxia and 70 eases of acute kidney injury after non-neonatal asphyxia.According to the staging criteria of acute kidney injury after neonatal asphyxia,there were 23 cases in phaseⅠ,14 cases in phaseⅡand 11 eases in phaseⅢ.Clinical data of 118 healthy neonates in the same period were collected retrospectively.The levels of L-FABP,Scr and BUN in children with different grades of acute kidney injury were compared between the two group,with different degrees of asphyxia,acute kidney injury after neonatal asphyxia and non-neonatal acute kidney injury after neonatal asphyxi-a,and the correlation between L-FABP and Scr and BUN was analyzed.Results The levels of L-FABP,Scr and BUN in the study group were higher than those in the control group(P<0.05).L-FABP,Scr and BUN levels in children with severe asphyxia were higher than those in children wdth mild asphyxia(P<0.05).The levels of L-FABP,Scr and BUN in children with acute kidney injury after neonatal asphyxia were higher than those in children without acute kidney injury after neonatal asphyxia(P<0.05).The levels of L-FABP,Scr and BUN in phaseⅠ,ⅡandⅢnewborn infants with acute kidney injury after neonatal asphyxia showed an increasing trend,and the differences among all groups were statistically significant(P<0.05).L-FABP levels were positively correlated with Scr and BUN levels in children with acute renal injury after neonatal asphyxia(r=0.632,P=0.004;r=0.725,P=0.008).Conclusions The expression of L-FABP,Scr,BUN in children with acute renal injury after neonatal asphyxia is increased.L-FABP is positively correlated with renal function indexes Scr and BUN,and the level of L-FABP increases with the degree of asphyxia and renal injury.
作者
蔡雅丽
张伟峰
康淑琴
吴联强
王瑞泉
刘志勇
陈江滨
Cai Yali;Zhang Weifeng;Kang Shuqin;Wu Lianqiang;Wang Ruiquan;Liu Zhiyong;Chen Jiangbin(Department of Neonatology,Quanzhou Childrens Hospital,Quanzhou 362000,China)
出处
《国际泌尿系统杂志》
2021年第6期1059-1062,共4页
International Journal of Urology and Nephrology
基金
泉州市科技计划项目(2019N047S)。
关键词
窒息
新生儿
急性肾损伤
肝型脂肪酸结合蛋白
Asphyxia,Neonatorum
Acute Kidney Injuiy
Liver Fatty Acid-Binding Protein
