摘要
目的:探讨原发性卵巢癌肉瘤的临床病理、治疗及预后。方法:收集广西医科大学附属肿瘤医院2008年1月至2019年5月收治的16例原发性卵巢癌肉瘤患者的资料进行回顾性分析。结果:16例患者就诊时中位年龄53岁,11例为绝经后患者。所有患者均有腹胀、腹痛等症状。治疗前均有CA125不同程度升高,伴有CA199(6例)、CA153(5例)、CEA(3例)、HE4(2例)、CA724(1例)、AFP(1例)升高。影像学提示边界欠清盆腔包块,依靠术后病理确诊。16例均接受手术治疗,其中12例接受铂类为基础的联合化疗。8例复发后继续接受治疗,2例行放疗。10例死亡。单因素及多因素分析显示,临床分期、术后化疗是原发性卵巢癌肉瘤独立的预后因素(均P<0.05)。结论:原发性卵巢癌肉瘤与其他卵巢癌临床表现无特异性,靠病理确诊,主要治疗方法为肿瘤细胞减灭术和含铂类为基础的化疗;临床分期、术后化疗是影响卵巢癌肉瘤患者预后的独立因素。
Objective:To investigate the clinicopathology,treatment and prognosis of primary carcinosarcoma in ovarys.Methods:The data of 16 patients with primary carcinosarcoma in ovarys treated in our hospital from January 2008 to May 2019 were retrospectively analyzed.Results:The median age of the 16 patients was 53 years,and 11 were postmenopausal.All patients had abdominal distension,abdominal pain and other symptoms.CA125 increased to varying degrees before treatment.CA199(6 cases),CA153(5 cases),CEA(3 cases),HE4(2 cases),CA724(1 case),AFP(1 case) were increased.Imaging suggested that the boundary was not clear pelvic mass.The diagnosis was confirmed by postoperative pathology.All 16 patients received surgery,and 12 patients received platinum-based combination chemotherapy.Eight patients continued to receive treatment after recurrence,and two underwent radiotherapy.There were 10 deaths.Univariate and multivariate analysis showed that clinical stage and postoperative chemotherapy were independent prognostic factors for primary carcinosarcoma in ovarys(P<0.05).Conclusion:Primary carcinosarcoma in ovarys has no specificity with other ovarian cancers and it is confirmed by pathology.The main treatment methods are tumor cell reduction and platinum-based chemotherapy.Clinical stage and postoperative chemotherapy are independent factors affecting the prognosis of patients with primary carcinosarcoma in ovarys.
作者
潘忠勉
李春
李力
Pan Zhongmian;Li Chun;Li Li(Department of Gynecologic Oncology,The Affiliated Tumor Hospital of Guangxi Medical University,Ministry of Education Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2021年第11期2179-2183,共5页
Journal of Guangxi Medical University
基金
广西科学研究与技术开发计划课题资助项目(No.桂科攻14124004)。
关键词
原发性卵巢癌肉瘤
诊断
治疗
预后
ovarian carcinosarcoma
diagnosis
treatment
prognosis
