摘要
目的探讨糖类抗原125(CA125)及血小板与淋巴细胞比值(PLR)早期诊断卵巢癌的应用价值。方法选取2015年6月至2019年6月北京京煤集团总医院、首都医科大学附属北京康复医院老年康复中心及中国中医科学院广安门医院收治的卵巢良性肿瘤患者40例为良性肿瘤组,卵巢癌患者40例为卵巢癌组,并于同期选取健康体检者40例为对照组。根据国际妇产科联盟(FIGO)分期标准将卵巢癌患者分为Ⅰ+Ⅱ期组(n=25)、Ⅲ+Ⅳ期组(n=15);并按照肿瘤分化程度将卵巢癌患者分为低分化组(n=12)、中分化组(n=19)及高分化组(n=9)。比较各组对象间CA125及PLR的水平,分析CA125及PLR在卵巢癌不同FIGO分期及不同分化程度中的水平变化。并采用受试者工作特征(ROC)曲线下面积(AUC)分析各参数对卵巢癌的诊断价值。结果良性肿瘤组、卵巢癌组CA125及PLR水平明显高于对照组(P<0.05),且卵巢癌组明显高于良性肿瘤组(P<0.05);Ⅲ+Ⅳ期组CA125及PLR水平明显高于Ⅰ+Ⅱ期组(P<0.05);低分化组、中分化组CA125及PLR水平明显高于高分化组(P<0.05),且低分化组明显高于中分化组(P<0.05);CA125及PLR诊断卵巢癌的AUC分别为0.873、0.832。结论卵巢癌患者CA125及PLR水平明显升高,随着卵巢癌病情加重,CA125及PLR水平越高,CA125及PLR在卵巢癌早期诊断中具有一定的诊断效能。
Objective To explore the application value of carbohydrate antigen 125(CA125)and platelet to lymphocyte ratio(PLR)in the early diagnosis of ovarian cancer.Methods Forty patients with benign ovarian tumor in the General Hospital of Beijing Beijing Coal Group,the Geriatric Rehabilitation Center of Affiliated Beijing Rehabilitation Hospital,Capital Medical University and Guang′anmen Hospital,China Academy of Chinese Medical Sciences from June 2015 to June 2019 were selected as the benign tumor group,40 patients with ovarian cancer as the ovarian cancer group and contemporaneous 40 subjects undergoing the healthy physical examination as the control group.According to the stage standard by the international federation of obstetrics and gynecolog(FIGO),the patients with ovarian cancer were divided into the stageⅠ+Ⅱgroup(n=25),stageⅢ+Ⅳgroup(n=15);according to the degree of tumor differentiation,the patients with ovarian cancer were divided into the low differentiation group(n=12),medium differentiation group(n=19)and high differentiation group(n=9).The levels of CA125 and PLR were compared among the groups,and the changes of CA125 and PLR levels in different FIGO stages and different differentiation levels of ovarian cancer were analyzed.The area under the receiver operating characteristic(ROC)curve(AUC)was used to analyze the value of each parameter in the diagnosis of ovarian cancer.Results The levels of CA125 and PLR in the benign ovarian tumor group and ovarian cancer group were evidently higher than those in the control group(P<0.05),moreover the ovarian cancer group was evidently higher than the benign ovarian tumor group(P<0.05);the levels of CA125 and PLR in the stageⅢ+Ⅳgroup were evidently higher than those in the stageⅠ+Ⅱgroup(P<0.05);the levels of CA125 and PLR in the low differentiation group and medium differentiation group were evidently higher than that in the highly differentiated group(P<0.05),moreover the low differentiation group was evidently higher than the medium differentiation group(P<0.05);the AUC values of CA125 and PLR for diagnosis of ovarian cancer were 0.873 and 0.832,respectively.Conclusion The levels of CA125 and PLR in the patients with ovarian cancer are increased significantly,and the more serious the development of ovarian cancer,the higher the levels of CA125 and PLR,moreover CA125 and PLR have certain diagnostic efficiency in the early diagnosis of ovarian cancer.
作者
黄利华
姜慧英
刘芳芳
乔婷婷
刘妮
高瑞珂
HUANG Lihua;JIANG Huiying;LIU Fangfang;QIAO Tingting;LIU Ni;GAO Ruike(Department of Clinical Laboratory,Beijing Jingmei Group General Hospital,Beijing 102300,China;Geriatric Rehabilitation Center,Affiliated Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100144,China;Department of Oncology,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《重庆医学》
CAS
2021年第23期3978-3981,共4页
Chongqing medicine
基金
国家重点研发计划“中医药现代化研究”项目(2018YFC1707405)。
