摘要
目的探讨上海市区及郊区成年人碘营养状况及其与甲状腺功能的关系,为成年人科学摄碘提供参考依据。方法选取上海市区及郊区成年人作为研究对象进行问卷调查,包括年龄、性别、身高、体重、尿碘浓度(UIC)、促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)。比较不同人群UIC、甲状腺功能及甲状腺自身抗体水平。logistic回归分析TPOAb和TGAb阳性的危险因素。线性回归分析TSH、T3和T4的危险因素。结果上海成年人整体UIC为195.50(139.10~287.45)μg/L;市区成年人UIC为206.25(141.30~309.03)μg/L,郊区成年人UIC为188.90(137.20~272.43)μg/L;男性成年人UIC为204.30(142.65~292.08)μg/L,女性成年人UIC为189.10(137.45~285.10)μg/L,UIC在郊区、市区及男、女性成年人间比较,差异均有统计学意义(P<0.05)。TSH水平女性成年人高于男性(2.70 mIU/L vs.2.29 mIU/L),郊区成年人高于市区(2.77 mIU/L vs.2.25 mIU/L);T3、T4水平郊区成年人低于市区(1.69 nmol/L vs.1.79 nmol/L,100.20 nmol/L vs.105.30 nmol/L)。在郊区和市区,不同碘营养状态的成年人TPOAb和TGAb阳性率比较,差异无统计学意义(P>0.05)。logistic回归分析显示,性别是TPOAb和TGAb阳性的主要危险因素。线性回归分析显示,居住地点是影响TSH、T3和T4水平的危险因素。结论上海成年人UIC处于碘适量状态,男、女性及郊区、市区成年人间UIC存在明显差异;在不同UIC的人群中甲状腺自身抗体水平差异不明显。
Objective To investigate the relationship between the iodine nutrition status and thyroid functions in both urban and suburban adults of Shanghai to provide references of scientific iodine intake for the residents.Methods The adults living in urban and suburban areas of Shanghai were selected as the study subjects.The questionnaire survey included the age,gender,height,body weight,urine iodine concentration(UIC),thyroid stimulating hormone(TSH),triiodothyronine(T3),tetraiodothyronine(T4),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb).UIC,thyroid function and autoimmune thyroid antibodies were compared among different groups.The risk factors of TPOAb and TGAb positivity were analyzed by the logistic regression.The linear regression was used to analyze the risk factors for TSH,T3 and T4.Results UIC in adults of Shanghai was 195.50(139.10-287.45)μg/L.UIC of urban adults was 206.25(141.30-309.03)μg/L and UIC of suburban adults was 188.90(137.20-272.43)μg/L;in males and females,UIC were 204.30(142.65-292.08)μg/L and 189.10(137.45-285.10)μg/L,respectively,there was statistically significant difference in UIC between urban and suburban adults and between males and females(P<0.05).The TSH level in females was higher than that in males(2.70 mIU/L vs.2.29 mIU/L).The TSH level in suburban adults was higher than that of urban adults(2.77 mIU/L vs.2.25 mIU/L).The T3 and T4 levels in suburban adults were lower than those in urban adults(1.69 nmol/L vs.1.79 nmol/L,100.20 nmol vs.105.30 nmol/L).There was no statistically significant difference in TPOAb and TGAb positivity rates between urban and suburban adults of different iodine nutrition status(P>0.05).The logistic regression analysis showed that gender was the major risk factor of TPOAb and TGAb positive.The linear regression analysis indicated that the residence place was the risk factor for affecting the TSH,T3 and T4 levels.Conclusion UIC is in adequate status for Shanghai adults.There is significant difference in UIC between males and females as well as between urban and suburban adults.However,the difference in the level of thyroid autoimmune antibodies among different UIC of populations is unobvious.
作者
韩兵
王宁荐
陈驰
俞洁
陈奕
陈颖超
程静
陆颖理
HAN Bing;WANG Ningjian;CHEN Chi;YU Jie;CHEN Yi;CHEN Yingchao;CHENG Jin;LU Yingli(Department of Endocrinology,Affiliated Ninth People′s Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200011,China)
出处
《重庆医学》
CAS
2021年第23期4105-4110,共6页
Chongqing medicine
基金
国家自然科学基金项目(81670717)
上海市科委基金项目(19140902400)。
关键词
上海市
碘营养状态
甲状腺功能
甲状腺自身抗体
Shanghai City
iodine nutrition status
thyroid function
thyroid autoantibody
