摘要
目的探究非霍奇金淋巴瘤(NHL)化疗患者外周血中性粒细胞计数/淋巴细胞计数比率(NLR)、血小板计数/淋巴细胞计数比率(PLR)和红细胞体积分布宽度(RDW)变化情况,分析其对肺部感染的预测价值。方法选取2018年3月至2021年3月在湖南中医药大学第一附属医院接受化疗的110例NHL患者(观察组)的临床资料,根据是否存在肺部感染将观察组患者分为肺部感染组、非肺部感染组和未感染组,根据感染程度将肺部感染组患者分为轻中度感染和重度感染,另选取同期体检的105例健康人群(对照组),比较各组外周血NLR、PLR和RDW表达水平,Logistic回归分析NHL化疗患者肺部感染的危险因素;受试者工作特征(ROC)曲线分析NLR、PLR和RDW对NHL化疗患者发生肺部感染的预测价值。结果外周血NLR、PLR和RDW水平:对照组<观察组化疗后<和观察化疗前,肺部感染组>非肺部感染组>未感染组,重度感染>轻中度感染,差异均有统计学意义(P<0.05)。Logistic回归分析显示,化疗前NLR、PLR和RDW水平是化疗后肺部感染的危险因素(P>0.05)。ROC曲线分析显示,NLR、PLR和RDW对肺部感染预测的AUC值分别为0.848、0.758和0.713(P<0.05)。结论NHL患者外周血NLR、PLR、RDW水平偏高,化疗后三者水平均有所改善,其水平变化对肺部感染的预测具有一定参考价值。
Objective To explore the changes of peripheral blood neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and red blood cell distribution width(RDW)in patients undergoing non-Hodgkin lymphoma(NHL)chemotherapy,and analyze their predictive value for lung infection.Methods A total of 110 patients undergoing chemotherapy for NHL in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine(observation group)and 105 healthy individuals(control group)were enrolled in this study between March 2018 and March 2021.According to presence or absence of lung infection,patients in the observation group were divided into the lung infection group,the non-lung infection group and the non-infection group.According to the severity of infection,patients in the lung infection group were divided into the mild,the moderate infection group and the severe infection group.Peripheral blood NLR,PLR and RDW were compared among the groups.Logistic regression analysis was performed to analyze the risk factors for lung infection in patients undergoing chemotherapy for NHL.The receiver operating characteristic(ROC)curve was used to analyze of the predictive value of the three indicators for lung infection in patients undergoing chemotherapy for NHL.Results The order of peripheral blood NLR,PLR and RDW was as follows:the control group<the observation group after chemotherapy<the observation group before chemotherapy.The lung infection group>the non-lung infection group>the non-infection group.The severe infection group>the moderate infection group>the mild infection group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that NLR,PLR and RDW before chemotherapy were risk factors of lung infection after chemotherapy(P>0.05).ROC curve analysis showed that the AUC values of NLR,PLR and RDW for predicting lung infection were 0.848,0.758 and 0.713,respectively(P<0.05).Conclusion The levels of NLR,PLR and RDW in the peripheral blood of NHL patients are relatively high,and the levels of the three have improved after chemotherapy.The changes in the three levels have certain reference value for the prediction of lung infection.
作者
刘蕾
易琴
聂甜
何娅娜
LIU Lei;YI Qin;NIE Tian;HE Yana(Department of Hematology and Oncology,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan,China,410000;Hunan University of Chinese Medicine,Changsha,Hunan,China,410000)
出处
《分子诊断与治疗杂志》
2021年第11期1800-1804,共5页
Journal of Molecular Diagnostics and Therapy
基金
湖南省自然科学基金资助项目(2018JJ40207)。
