摘要
目的:探讨厦门地区老年人非酒精性脂肪性肝病(Non-alcoholic Fatty Liver Disease,NAFLD)患者的中医证型分布特点及证型与血清生化指标的相关性。方法:研究对象来自厦门市湖里区禾山街道社区卫生服务中心体检的老年NAFLD患者。收集研究对象的人口统计学资料、慢性基础疾病情况和血清生化指标,并对其进行中医证型判断。分析中医证型分布特点及各证型与血清生化指标之间的相关性。结果:1203例老年NAFLD患者中,肝郁脾虚证、湿浊内停证、湿热蕴结证、痰瘀互结证、脾肾两虚证各占总数的14.05%(169/1203)、30.92%(372/1203)、27.76%(334/1203)、11.22%(135/1203)、16.04%(193/1203)。以证型为标准对患者进行分组,患者的平均年龄无显著组间差异(P=0.083),性别分布基本一致(P=0.117)。五种证型组老年患者肥胖(P<0.001)、高血压病(P=0.049)、糖尿病(P=0.003)及高尿酸血症(P=0.001)的患病率均存在显著差异。不同证型组老年NAFLD患者的身体质量指数(P<0.001)、空腹血糖(P=0.022)、尿酸(P<0.001)、总胆固醇(P<0.001)、高密度脂蛋白(P<0.001)及低密度脂蛋白(P<0.001)差异有统计学意义。结论:本研究发现,厦门地区老年NAFLD患者以湿浊内停型为主要证型,以该证型为主开展针对该证型的中医治疗,将有显著的疗效。同时,老年NAFLD患者的证型与肥胖、高血压病、糖尿病、高尿酸血症等基础疾病密切相关,因此在老年人群NAFLD的防治中要重视慢性基础疾病的管理。
Objective:To investigate the distribution characteristics of the traditional Chinese medicine(TCM)syndromes in elderly patients with non-alcoholic fatty liver disease in Xiamen area and the correlation between the syndromes and serum biochemical indexes.Methods:The subjects were aged patients with NAFLD who underwent physical examination in Heshan Street Community Health Service Center,Huli District,Xiamen area.The demographic data,chronic basic diseases and serum biochemical indexes of the subjects were collected,and the TCM syndromes were judged.The distribution characteristics of TCM syndromes,and the correlation between various syndromes and serum biochemical indexes were analyzed.Results:In 1203 elderly NAFLD patients,the liver stagnation of with spleen deficiency,congestion of dampness turbidity,accumulation and binding of damp-heat,intermin-gled phlegm and blood stasis,spleen and kidney deficiency accounted for 14.05%(169/1203),30.92%(372/1203),27.76%(334/1203),11.22%(135/1203)and 16.04%(193/1203)respectively.Patients were grouped according to the TCM syndrome.The mean age of patients was not significantly different between groups(P=0.083),and the gender distribution was basically the same(P=0.117).Obesity(P<0.001),hypertension(P=0.049),diabetes(P=0.003)and hyperuricemia(P=0.001)were significantly different in five TCM syndromes groups.And the BMI(P<0.001),GLU(P=0.022),UA(P<0.001),TC(P<0.001),HDL(P<0.001)and LDL(P<0.001)were significantly different in different TCM syndromes groups.Conclusion:This study found that the main TCM syndromes of elderly NAFLD patients in Xiamen area are congestion of dampness turbidity,and the Chinese medicine treatment based on this TCM syndrome will have a significant effect.At the same time,the TCM syndrome type of elderly NAFLD patients is closely related to obesity,hypertension,diabetes,hyperuricemia,so the management of chronic basic diseases should be emphasized in the prevention and treatment of NAFLD in the elderly.
出处
《中医临床研究》
2021年第28期27-30,共4页
Clinical Journal Of Chinese Medicine
基金
厦门市重要重大疾病联合攻关项目(3502720179047)
厦门市医疗卫生指导性项目(3502Z202009121)
国家级自然科学基金资助项目(81873242)。
关键词
老年人
非酒精性脂肪性肝病
中医证型
血清生化指标
Elderly person
Non-alcoholic fatty liver disease
TCM syndrome
Serum biochemical index
