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培门冬酶与左旋门冬酰胺酶治疗儿童急性淋巴细胞白血病的疗效及安全性观察 被引量:4

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摘要 儿童急性淋巴细胞白血病主要表现贫血、脸色苍白乏力、盗汗、低热等现象,或出现呼吸道感染症状,会反复发作,需进行治疗来控制病情[1]。此病好发在9岁以内的儿童,联合化疗是白血病治疗的原则[2]。主要目的是杀灭白血病细胞,清除体内的微量残留白血病细胞,恢复骨髓造血功能,尽量减少正常组织损伤,减少晚期治疗后遗症[3]。左旋门冬酰胺酶治疗儿童急性淋巴细胞白血病能够阻碍肿瘤细胞的蛋白质合成及增殖,也可干扰细胞DNA、RNA的合成[4]。但在临床上需反复、持续注射,停药复发率较高导致应用受限。
作者 王长爽
出处 《中国药物与临床》 CAS 2021年第23期3871-3873,共3页 Chinese Remedies & Clinics
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