摘要
目的:探索注意缺陷多动障碍儿童静态以及动态功能连接的异常。方法:收集智商高于80的6~16岁符合DSM-IV诊断的注意缺陷多动障碍儿童97例(男78例,女19例)和年龄匹配的正常对照儿童74例(男45例,女29例)的静息态功能磁共振成像数据,比较两组全脑静态功能连接和动态功能连接指标。结果:注意缺陷多动障碍组的静态功能连接与正常对照组的差异无统计学意义(P>0.05),注意缺陷多动障碍组腹外侧前额叶与全脑其他脑区功能连接的模式变异性大于正常对照组[(0.65±0.07)%vs.(0.60±0.08)%,P<0.01]。结论:动态分析提示腹外侧前额叶是注意缺陷多动障碍的关键脑区,为理解疾病的脑机制提供可能的新视角。
Objective:To investigate static and dynamic resting-state functional connectivity in children with attention-deficit/hyperactivity disorder(ADHD).Methods:Totally 97 children aged 6 to 16 years old,with intelligence quotient(IQ)≥80,meeting criteria of ADHD of the Diagnostic and Statistical Manual of Mental Disorder,Fourth Edition(DSM-Ⅳ)and 74 typically developing normal children matched with age and IQ were recruited.The functional magnetic resonance imaging was used The group difference of static functional connectivity and dynamic functional connectivity metrics were compared respectively.Results:There was no group difference in static functional connectivity(P>0.05).The dynamic functional connectivity of ventrolateral prefrontal cortex was higher in children with ADHD than in normal controls[(0.65±0.07)%vs.(0.60±0.08)%,P<0.01].Conclusion:Dynamic analysis suggests that ventrolateral prefrontal cortex is related to ADHD and may provide new perspective for understanding ADHD brain mechanisms.
作者
谢娆
高煦平
赵驿鹭
钟苑心
孙霄
杨智
杨莉
曹庆久
XIE Rao;GAO Xuping;ZHAO Yilu;ZHONG Yuanxin;SUN Xiao;YANG Zhi;YANG Li;CAo Qingju(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 10083,China;School of Computer Science,Peking University,Beijing 100083,China)
出处
《中国心理卫生杂志》
CSCD
北大核心
2022年第1期80-86,共7页
Chinese Mental Health Journal
基金
国家重点研发计划重大慢性非传梁性疾病防控研究重点专项(2016YFC1306103)
国家自然科学基金项目(81671358、81873804)
北京大学临床医学+X青年专项联合研究项目。
关键词
注意缺陷多动障碍
动态功能连接
腹外侧前额叶
attention-deficit/hyperactivity disorder
dynamic functional connectivity
ventrolateral prefrontal cortex
