摘要
目的分析脑出血后抑郁患者血清神经酰胺C16、C24水平及其比值变化情况,探讨脑出血后抑郁的影响因素。方法收集2018年7-11月首都医科大学附属北京康复医院60例脑出血后患者纳入观察组,根据抑郁自评量表(SDS)评分分为脑出血后抑郁组和脑出血后非抑郁组。同时随机选择同年龄段的体检健康者10例纳入健康对照组。比较脑出血后抑郁组与脑出血后非抑郁组的基线资料、血液学指标,比较不同病程组患者与健康对照者血清神经酰胺水平;分析脑出血后抑郁的影响因素。结果血清神经酰胺C16、C16/C24在脑出血后<1个月组最高,健康对照组最低,多重比较显示,脑出血后<1个月组的血清神经酰胺C16水平、C16/C24与健康对照组比较,差异均有统计学意义(P<0.05),其他各组之间比较,差异均无统计学意义(P>0.05)。随着病程的进展,血清神经酰胺C16、C24及C16/C24总体上有逐渐向健康人群水平接近的趋势。多因素Logistic回归分析显示,血清神经酰胺C16水平升高可能是脑出血后抑郁发生的危险因素;血清神经酰胺C16诊断脑出血后抑郁的受试者工作特征曲线下面积为0.798。结论血清神经酰胺C16水平升高可能会增加脑出血患者抑郁发生的风险,C16有望成为诊断脑出血后抑郁的生物标志物之一。
Objective To analyze the changes of serum ceramide C16,C24 levels and their ratios in patients with depression after intracerebral hemorrhage,and to explore the influencing factors of depression after intracerebral hemorrhage.Methods A total of 60 patients with intracerebral hemorrhage in Beijing Rehabilitation Hospital,Capital Medical University from July to November 2018 were enrolled into the observation group.According to the self-rating Depression Scale(SDS)score,they were divided into the post-intracerebral depression group and the non-depressed group.At the same time,10 healthy subjects of the same age were randomly selected into the healthy control group.The baseline data and hematological indexes of post-intracerebral depression group and non-depressed group were compared,and the serum ceramide levels of patients with different course of disease and healthy controls were compared.To analyze the influencing factors of depression after intracerebral hemorrhage.Results The levels of serum ceramide C16 and C16/C24 were the highest in<1 month group after intracerebral hemorrhage,and the lowest in healthy control group.Multiple comparisons showed that the levels of serum ceramide C16 and C16/C24 in<1 month group after intracerebral hemorrhage were significantly different from those in healthy control group(P<0.05),there was no significant difference among other groups(P>0.05).With the progression of the disease,serum ceramide C16,C24 and C16/C24 gradually approached the level of healthy people.Multivariate Logistic regression analysis showed that increased serum ceramide C16 level might be a risk factor for depression after intracerebral hemorrhage.The area under the receiver operating characteristic curve of ceramide C16 for diagnosis depression after intracerebral hemorrhage was 0.798.Conclusion Elevated C16 level might increase the risk of depression after intracerebral hemorrhage,and it is expected to become one of the biomarkers for the diagnosis of depression after intracerebral hemorrhage.
作者
王洪美
郑光辉
刘建华
吕虹
张国军
WANG Hongmei;ZHENG Guanghui;LIU Jianhua;LYU Hong;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Clinical Laboratory,Beijing Rehabilitation Hospital,Capital Medical University,Capital Medical University,Beijing 100144,China)
出处
《国际检验医学杂志》
CAS
2021年第24期2958-2962,共5页
International Journal of Laboratory Medicine
