摘要
目的探讨白细胞介素(IL)-8、IL-12评估急性呼吸窘迫综合征(ARDS)患者预后的价值。方法回顾性分析2019年1月至2021年2月滕州市中医医院ICU接收的ARDS患者67例临床资料,男39例、女28例,以ARDS起病28 d内的结局作为分组标准,分为存活组48例、死亡组19例。比较两组患者入院时及第2天的IL-8、IL-12水平;Spearman相关性分析IL-8、IL-12与ARDS患者预后的关联;受试者工作特征曲线(ROC)分析入院时及第2天IL-8、IL-12对ARDS预后的预测价值。结果两组患者性别、体质量指数(BMI)、吸烟史、饮酒史、高血压、糖尿病、冠心病比例比较,差异均无统计学意义(均P>0.05);死亡组的年龄、白细胞计数(WBC)、中性粒细胞(N)计数分别为(71.45±7.12)岁、(13.17±2.92)×10^(9)/L、(5.30±1.49)×10^(9)/L,均高于存活组(64.40±10.18)岁、(10.48±3.78)×10^(9)/L、(4.58±1.17)×10^(9)/L,氧合指数(OI)为(134.18±35.60),低于存活组(175.42±49.38),差异均有统计学意义(均P<0.05)。入院时、第2天,死亡组IL-8水平分别为(192.35±54.22)ng/L、(179.60±42.60)ng/L,IL-12水平分别为(95.70±24.70)ng/L、(86.14±15.50)ng/L,均高于存活组的(138.60±30.18)ng/L、(10^(9).30±21.29)ng/L及(70.50±16.79)ng/L、(66.78±12.24)ng/L,差异均有统计学意义(均P<0.05)。ROC分析显示,入院时及第2天的IL-8、IL-12水平对预后有一定的预测价值,其中第2天的IL-8预测效能最佳,曲线下面积为0.815;以第2天的IL-8≥148.00 ng/L作为预测ARDS患者死亡的截断点,灵敏度为84.21%,特异度为81.25%。结论ARDS患者IL-8、IL-12与预后密切相关,IL-8、IL-12可作为预测ARDS预后指标,并为临床治疗提供指导。
Objective To explore the values of interleukin(IL)-8 and IL-12 in evaluating the prognosis of patients with acute respiratory distress syndrome(ARDS).Methods The clinical data of 67 patients with ARDS received by the ICU of Traditional Chinese Medicine Hospital of Tengzhou City from January 2019 to February 2021 were retrospectively analyzed,including 39 males and 28 females.With the outcome within 28 days after the onset of ARDS as the grouping criteria,they were divided into a survival group(48 cases)and a death group(19 cases).The levels of IL-8 and IL-12 at admission and on the second day of the two groups were compared.The Spearman correlation analysis was used to analyze the correlation between IL-8,IL-12,and the prognosis of ARDS patients.The receiver operating characteristic curve(ROC)was used to analyze the values of IL-8 and IL-12 in predicting the prognosis of ARDS.Results There were no statistically significant differences in the gender,body mass index(BMI),smoking history,drinking history,proportion of hypertension,diabetes,and coronary heart disease between the two groups(all P>0.05).The age,white blood cell(WBC)count,and neutrophil(N)count in the death group were(71.45±7.12)years old,(13.17±2.92)×10^(9)/L,and(5.30±1.49)×10^(9)/L,respectively,which were higher than those in the survival group[(64.40±10.18)years,(10.48±3.78)×10^(9)/L,and(4.58±1.17)×10^(9)/L],and the oxygenation index(OI)was(134.18±35.60),which was lower than that in the survival group[(175.42±49.38)],with statistically significant differences(all P<0.05).The levels of IL-8 in the death group at admission and on the second day were(192.35±54.22)ng/L and(179.60±42.60)ng/L,the levels of IL-12 were(95.70±24.70)ng/L and(86.14±15.50)ng/L,which were higher than those in the survival group[(138.60±30.18)ng/L,(10^(9).30±21.29)ng/L,(70.50±16.79)ng/L,and(66.78±12.24)ng/L],with statistically significant differences(all P<0.05).The ROC analysis showed that the levels of IL-8 and IL-12 at admission and on the second day had certain predictive values for the prognosis of ARDS.Among them,the IL-8 level on the second day had the best predictive performance,with an area under the curve of 0.815.Taking IL-8≥148.00 ng/L on the second day as the cut-off point for predicting the death of ARDS patients,the sensitivity was 84.21%and the specificity was 81.25%.Conclusions IL-8 and IL-12 are closely related to the prognosis of ARDS patients.IL-8 and IL-12 can be used as indicators to predict the prognosis of ARDS and provide guidance for clinical treatment.
作者
程俐
黄健
Cheng Li;Huang Jian(Departmnet of Critical Care Medicine,Traditional Chinese Medicine Hospital of Tengzhou City,Tengzhou 277599,China)
出处
《国际医药卫生导报》
2021年第24期3850-3854,共5页
International Medicine and Health Guidance News
