摘要
动脉粥样硬化(AS)是一种慢性持续进展、过程复杂的炎症性血管病变,是心脑血管疾病最主要的病理因素,在中老年人群中普遍存在,且随年龄增长呈渐进性病变,发病率呈逐年上升趋势。血管内皮细胞作为直接接触血液的细胞,具有调节血管生成、免疫反应、营养交换及血管张力等生理学功能。细胞自噬是一个高度保守的亚细胞降解过程,可维持细胞质成分周转,以响应代谢需求,而自噬在AS发生发展过程中具有两面性,适度自噬可保护细胞免受环境刺激的影响,自噬过度或不足又可引发疾病。天然中药中众多活性单体及其衍生物具备抗AS的活性,甚至可影响其获得性耐药,而对自噬的调控多被证实为其潜在的作用机制。旨在探讨内皮细胞自噬水平与AS的关系及中药单体以自噬为靶点对AS的影响。
Objective Atherosclerosis(AS)is a chronic,continuous and complex inflammatory vascular disease.It is the most important pathological factor and pathological product of cardiovascular and cerebrovascular diseases.It is common in middle-aged and elderly people,and gradually progresses with age.The incidence is increasing year by year.As cells that directly contact the blood,vascular endothelial cells have physiological functions such as regulating angiogenesis,immune response,nutrient exchange and vascular tension.Autophagy is a highly conservative subcellular degradation process that can maintain the turnover of cytoplasmic componentsin response to metabolic demands.Autophagy has two sides in the development and development of AS.Modern autophagy can protect cells from environmental stimuli.Excessive or insufficient phagocytosis can cause disease.Many active monomers and their derivatives in natural Chinese medicine possess anti-AS activity,which can even affect their acquired resistance,and the regulation of autophagy has been proved to be its potential mechanism.This article aimed to explore the relationship between endothelial cell autophagy levels and AS and the effect of traditional Chinese medicine monomers on AS based on autophagy.
作者
赵立凤
于红红
田维毅
ZHAO Lifeng;YU Honghong;TIAN Weiyi(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第11期117-120,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(81760790,81860779)
贵州省科技创新人才团队项目(黔科合平台人才[2020]5010)
贵州省国内一流建设学科项目(GNYL[2017]008号)。
关键词
动脉粥样硬化
中药单体
血管内皮细胞
自噬
atherosclerosis
Chinese herbal monomer
vascular endothelial cells
autophagy
