摘要
雷公藤甲素(TP)是从卫矛科植物雷公藤中分离出的一种环氧化二萜内酯化合物,是雷公藤的主要活性成分之一,具有免疫活性、抗炎、抗风湿和抗肿瘤作用。然而,TP水溶性差,体内消除快,高活性的TP可诱发多器官毒性,阻碍了其在临床中的应用。主要对近3年来TP在基础研究中的不良反应及机制,剂型及给药方式转换,配伍减毒等多方面进行整合归纳,以期为TP的毒性作用及减毒增效研究的深入探索提供参考。
Triptolide(TP),an epoxide diterpene lactone compound isolated from Leigongteng(Tripterygium wilfordii),is one of the main active components.TP has immunological activity,anti-inflammatory,anti-rheumatic and anti-tumor effects.However,TP has poor water solubility,fast elimination in vivo.Highly active TP can induce multi-organ toxicity,hindering the development of its preparations and its clinical application.This article mainly summarized its toxicities and mechanisms of TP in basic research in the past three years,such as the conversion of dosage forms,administration methods and compatibility attenuation,with a view to in-depth exploration of toxicity and attenuation of TP and enhancing efficiency research for reference.
作者
严银银
张振强
曾华辉
闫敏
YAN Yinyin;ZHANG Zhenqiang;ZENG Huahui;YAN Min(School of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第11期139-143,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(U1604185)
河南省科技攻关项目(192102310440)
河南省高等学校重点科研项目(19A360021)
河南中医药大学科研苗圃工程项目(MP2020-13)。
关键词
雷公藤甲素
不良反应
作用机制
配伍
剂型
triptolide
toxic side effect
action mechanism
compatibility
dosage form
