摘要
糖尿病肾病(diabetic nephropathy, DN)是导致终末期肾脏疾病的主要原因,也是发生心血管疾病的一个独立风险因素,严重影响人类健康。缓解并治疗DN已经成为当前终末期肾脏疾病的重要研究方向。脂肪间充质干细胞(adipose-derived stem cells, ADSCs)是一种来自脂肪组织的成体干细胞,由其产生的外泌体能在细胞间传递蛋白质、mRNAs和miRNAs等物质,并广泛参与细胞间信号传输,通过调节免疫反应、促进自噬、抑制凋亡及缓解足细胞上皮-间充质转换过程来影响或改变受体细胞的行为,减缓DN的发生发展。因此,ADSCs外泌体在DN治疗中显示出广阔的应用前景。本文主要就ADSCs外泌体在DN中的保护作用及其机制进行综述。
Diabetic nephropathy(DN) is the main cause of end-stage kidney disease and an independent risk factor for cardiovascular disease, which seriously affects human health. Relieving and treating DN have become an important direction of current research in end-stage kidney disease. Adipose-derived stem cells(ADSCs) are adult stem cells from adipose tissue. The exosomes secreted from ADSCs transmit proteins,mRNAs and miRNAs between various cells, relieve the development of DN by regulating the immune response, promoting autophagy, suppressing apoptosis, and alleviating the epithelial-interstitial transition process of foot cells. Therefore, ADSCs exosomes have shown broad application prospects in DN therapy.This paper mainly reviews and discusses the protective effect and mechanism of ADSCs exosomes in DN.
作者
王君仪
陈柯宇
孙明坤
邵金昂
吴恒超
胡玉鑫
徐苑苑
WANG Junyi;CHEN Keyu;SUN Mingkun;SHAO Jin'ang;WU Hengchao;HU Yuxin;XU Yuanyuan(School of Public Health,China Medical University,Shenyang 110122,China)
出处
《生命的化学》
CAS
2021年第10期2111-2118,共8页
Chemistry of Life
基金
国家重点研发计划项目(2018YFC1311600)。
