摘要
目的:探讨氨溴索治疗慢阻肺合并肺部感染患者的效果及对气道阻力的影响。方法:选取本院2019年1月-2021年1月收治的慢阻肺合并肺部感染患者100例为研究对象,采用随机数字表法将其分为对照组(给予常规治疗)和研究组(在对照组基础上给予氨溴索治疗),每组50例。比较两组患者的临床综合疗效,治疗前后的气道阻力指标、气道重塑指标,临床症状消失时间。结果:治疗15、30 d后,研究组患者的总有效率均高于对照组,差异均有统计学意义(P<0.05);治疗15、30 d后,研究组的气道阻力指标、气道重塑指标均优于对照组,差异均有统计学意义(P<0.05);研究组患者的咳嗽、气促、胸闷和肺部啰音消失时间均短于对照组,差异均有统计学意义(P<0.05)。结论:采用氨溴索治疗慢阻肺合并肺部感染患者的临床效果显著,能够显著改善患者气道阻力、气道重塑,促进患者尽快恢复,是临床治疗慢阻肺合并肺部感染的可靠方法之一。
Objective:To investigate the effect of Ambroxol on chronic obstructive pulmonary disease complicated with pulmonary infection and its effect on airway resistance.Method:From January 2019 to January 2021,100 patients with chronic obstructive pulmonary disease complicated with pulmonary infection treated in our hospital were selected as the research objects.They were randomly divided into control group (routine treatment) and study group (Ambroxol treatment on the basis of control group),with 50 cases in each group.The clinical comprehensive efficacy,airway resistance index,airway remodeling index and the disappearance time of clinical symptoms were compared between the two groups.Result:After 15 and 30 d of treatment,the total effective rates of the study group were higher than those of the control group,the differences were statistically significant (P<0.05);after 15 and 30 d of treatment,the indexes of airway resistance and airway remodeling in the study group were better than those in the control group,the differences were statistically significant (P<0.05);the disappearance time of cough,shortness of breath,chest tightness and pulmonary rales in the study group were shorter than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Ambroxol has a significant clinical effect in the treatment of COPD patients with pulmonary infection,it can significantly improve the airway resistance and airway remodeling,and promote the recovery of patients as soon as possible,it is one of the reliable methods for the clinical treatment of COPD patients with pulmonary infection.
作者
尹照萍
YIN Zhaoping(Panjin Liaoyou Baoshihua Hospital,Panjin 124010,China)
出处
《中国医学创新》
CAS
2021年第32期27-30,共4页
Medical Innovation of China
关键词
氨溴索
慢阻肺
肺部感染
气道阻力
Ambroxol
COPD
Pulmonary infection
Airway resistance
