摘要
目的观察戈舍瑞林联合腹腔镜手术治疗重度卵巢子宫内膜异位囊肿的疗效。方法选取2017年1月—2018年12月收治的78例重度卵巢子宫内膜异位囊肿患者,根据治疗方法分为对照组(38例,采用腹腔镜保守性手术治疗)和观察组(40例,在腹腔镜保守性治疗基础上联合应用戈舍瑞林治疗)。比较两组患者的治疗效果、手术满意率、手术后住院时间、性激素指标、复发率及妊娠率。结果观察组治愈率为77.50%(31/40),高于对照组的65.79%(25/38),差异有统计学意义(χ^(2)=4.320,P<0.05)。观察组手术满意率为92.50%(37/40),显著高于对照组的81.58%(31/38),观察组手术后住院时间短于对照组,差异均有统计学意义(均P<0.05)。观察组患者术后3个月和6个月血清卵泡刺激素(FSH)水平分别为(41.24±1.95)U/L和(42.11±1.23)U/L,均高于对照组的(30.15±2.38)U/L和(33.46±1.72)U/L,血清黄体生成素(LH)水平分别为(42.18±2.52)U/L和(44.54±2.07)U/L,均高于对照组的(33.60±3.12)U/L和(35.22±1.91)U/L,血清雌二醇(E_(2))水平分别为(41.67±2.69)pmol/L和(39.55±4.02)pmol/L,均低于对照组的(58.42±2.70)pmol/L和(53.26±3.14)pmol/L,差异均有统计学意义(均P<0.05)。观察组患者复发率为7.50%(3/40),明显低于对照组的23.68%(9/38),差异有统计学意义(P<0.05)。结论戈舍瑞林联合腹腔镜手术治疗重度卵巢子宫内膜异位囊肿疗效较好,可调节血清性激素水平,降低患者复发率。
Objective To observe the curative effect of goserelin combined with laparoscopic surgery in treatment of severe ovarian endometriosis cyst.Methods Seventy-eight patients with severe ovarian endometriosis cyst were selected from January 2017 to December 2018,then they were divided into control group(38 patients,laparoscopic conservative surgery)and observation group(70 patients,laparoscopic conservative surgery combined with goserelin)according to treatment method.The curative effects,satisfaction rates of operation,postoperative hospitalization time,sex hormones,recurrence rates,and pregnancy rates in the two groups were compared.Results The cure rate in observation group was 77.50%(31/40),which was statistically significantly higher than that in control group(65.79%,25/38)(χ^(2)=4.320,P<0.05).The satisfaction rate of operation in observation group was 92.50%(37/40),which was statistically significantly higher than that in control group(81.58%,31/38),the postoperative hospitalization time in observation group was statistically significantly shorter than that in control group(P<0.05).The levels of serum follicle-stimulating hormone(FSH)at 3 and 6 months after operation in observation group were(41.24±1.95)U/L and(42.11±1.23)U/L,respectively,which were statistically significantly higher than those in control group[(30.15±2.38)U/L and(33.46±1.72)U/L];the levels of serum luteinizing hormone(LH)at 3 and 6 months after operation in observation group were(42.18±2.52)U/L and(44.54±2.07)U/L,respectively,which were statistically significantly higher than those in control group[(33.60±3.12)U/L and(35.22±1.91)U/L];the levels of serum estradiol(E_(2))at 3 and 6 months after operation in observation group were(41.67±2.69)pmol/L and(39.55±4.02)pmol/L,respectively,which were statistically significantly lower than those in control group[(58.42±2.70)pmol/L and(53.26±3.14)pmol/L](P<0.05).The recurrence rate in observation group was 7.50%(3/40),which was statistically significantly lower than that in control group(23.68%,9/38)(P<0.05).Conclusion The curative effect of goserelin combined with laparoscopic surgery in treatment of severe ovarian endometriosis cyst is good,the method can regulate serum levels of sex hormones and reduce the recurrence rate.
作者
支霜
蒋本贵
严力锋
冯嫣
ZHI Shuang;JIANG Ben-Gui;YAN Li-Feng(The Fourth Department of Gynecology,Ningbo Women and Children’s Hospital,Ningbo,Zhejiang 315000,China)
出处
《中国妇幼保健》
CAS
2021年第24期5722-5725,共4页
Maternal and Child Health Care of China
基金
浙江省医药卫生科技计划项目(2016KYB168)。
