摘要
目的探讨倒班、平均睡眠时间及其联合作用对钢铁工人肝功能异常的影响,为保护钢铁工人肝脏提供理论依据。方法采用横断面研究,以某钢铁公司6907名工人作为研究对象,并收集信息。采用非条件Logistic回归分析模型和限制性立方样条函数进行分析。结果肝功能异常的检出率为18.0%,且男性高于女性(19.2%vs.5.1%)。调整混杂因素后,倒班年限和肝功能异常之间存在非线性剂量反应关系。倒班和平均倒班频率>7夜/月患肝功能异常的风险分别增加1.24倍(OR=1.24,95%CI:1.04~1.49)和1.29倍(OR=1.29,95%CI:1.07~1.56)。以倒班状态分层,在倒班工人中平均睡眠时间较短(≤5 h/d)和较长(>7 h/d)患肝功能异常的风险分别增加1.19倍(OR=1.19,95%CI:1.01~1.43)和1.22倍(OR=1.22,95%CI:1.02~1.44)。且平均睡眠时间较长或较短均与倒班存在正向相乘的交互作用。根据平均睡眠时间分层后,平均睡眠时间>5~7 h/d的各倒班指标与肝功能异常的联系无统计学意义。结论倒班工作和睡眠时间较长或较短联合作用会增加钢铁工人肝功能异常的风险,倒班工作对肝功能异常的独立作用也不容忽视。
Objective To investigate the effects of rotating night shift work and average sleep duration and their combined effects on liver dysfunction of steelworkers,and to provide theoretical basis for liver protection of steelworkers.Methods In this cross-sectional study,a total of 6907 workers from a steel company were recruited,and their indicators were collected.These indicators were analyzed by the unconditional Logistic regression model and the restricted cubic spline function.Results The detection rate of liver dysfunction was 18.0%,which was significantly higher in males than in females(19.2%vs.5.1%).After adjusting for the confounding factors,there was a non-linear dose-response relationship between duration of night shifts and liver dysfunction,and the odds of liver dysfunction in night shift workers and average frequency of night shifts>7 nights/month were increased by 1.24(OR=1.24,95%CI:1.04-1.49)and 1.29(OR=1.29,95%CI:1.07-1.56),respectively.When stratified by current shift status,compared with the average sleep duration of>5-7 h/d,the odds of liver dysfunction in shorter sleep duration(≤5 h/d)and longer sleep duration(>7 h/d)were increased by 1.19(OR=1.19,95%CI:1.01-1.43)and 1.22(OR=1.22,95%CI:1.02-1.44)among night shift workers.And there was a positive interaction between longer or shorter average sleep duration and current shift status.After stratified by average sleep duration,only in the layer with an average sleep duration of>5-7 h/d,there was no statistically significant relationship between different exposure metrics of night shift work and liver function.Conclusion The combined effects of rotating night shift work and longer or shorter sleep duration increases the risk of liver dysfunction,and the independent effects of rotating night shift work cannot be ignored.
作者
李庆林
王涵
张晓红
薛超
秦盛
张生奎
袁聚祥
LI Qing-lin;WANG Han;ZHANG Xiao-hong;XUE Chao;QIN Sheng;ZHANG Sheng-kui;YUAN Ju-xiang(Department of Epidemiology and Health Statistics,School of Public Health,North China University of Science and Technology,Tangshan 063210,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2021年第11期1347-1353,共7页
Chinese Journal of Disease Control & Prevention
基金
国家科技部重点科研项目(2016YFC0900605)
河北省重点职业病防治技术研究(13277709D)。
关键词
倒班工作
睡眠时间
肝功能异常
横断面研究
Rotating night shift work
Sleep duration
Liver dysfunction
Cross-sectional study
