摘要
[Objectives]To explore the mechanism of coriander in the treatment of osteoarthritis by means of network pharmacology.[Methods]The effective active components of coriander and their targets were screened from TCMSP database.The targets related to osteoarthritis were screened from CTD database.The targets of active components were matched with the targets of diseases to obtain potential targets.PPI was constructed by using STRING database,and key target proteins were selected according to the degree value and the medium number.The DAVID database is used to analyze the biological functions and pathways of potential targets.[Results]15 active components of coriander were screened out by using OB and DL,and corresponding 102 targets were found,of which 45 were intersected with osteoarthritis-related targets,and PPI network contains 45 targets.The enrichment analysis of go includes 100 items,including 72 items related to biological processes,17 items related to cell components,11 items related to molecular functions,and 62 items related to KEGG pathway.[Conclusions]The results of network pharmacological analysis in this study indicate that the effective active ingredients of coriander mainly act on key targets such as CASP3,IL6,ALB,VEGFA,EGFR,MYC,CCND1,PPARG,FOS,RELA,etc.Multiple signal pathways such as p53 and PIK-AKt regulate the expression of genes to achieve the purpose of treating osteoarthritis,and lay a certain foundation for the mechanism of coriander to treat osteoarthritis.
基金
National Natural Science Foundation of China(82060303)
Guangxi Natural Science Foundation Youth Project(2018GXNSFBA294007)
Open Project of Key Laboratory of Ministry of Education—Research on Early Prevention and Treatment of Regional High-incidence Tumors(GKE2017KF02)
Self-funded Scientific Research Project of Guangxi Health Commission(Z2014426).
