摘要
目的探讨旋覆代赭汤加减联合西药治疗脑卒中后呃逆的临床效果。方法选取2018年12月至2019年6月沈阳市骨科医院承基医院神经内科收治的100例脑卒中后呃逆患者作为研究对象,采用随机数字表法将其分为氯丙嗪组和联合治疗组,每组各50例。氯丙嗪组患者采用常规临床医学治疗,予盐酸氯丙嗪25 mg/次,2次/d,口服。联合治疗组患者在氯丙嗪组治疗基础上同时予旋覆代赭汤加减。两组患者的治疗周期均为21 d。比较两组患者治疗前后的半身不遂、言语蹇涩、口角歪斜、喉间呃声不断、周身乏力、胃脘部隐痛评分;比较两组患者治疗前后的王氏评分表评分和呃逆疗效评分;比较两组患者治疗前后的血Ca^(2+)、Na^(+)含量;比较两组患者的治疗总有效率。结果两组患者治疗后的半身不遂、言语蹇涩、口角歪斜、喉间呃声不断、周身乏力、胃脘部隐痛评分均低于治疗前,差异有统计学意义(P<0.05);联合治疗组患者治疗后的半身不遂、言语蹇涩、口角歪斜、喉间呃声不断、周身乏力、胃脘部隐痛评分均低于氯丙嗪组,差异有统计学意义(P<0.05)。两组患者治疗后的呃逆疗效评分均低于治疗前,差异有统计学意义(P<0.05);联合治疗组患者治疗后的呃逆疗效评分均低于氯丙嗪组,差异有统计学意义(P<0.05)。两组患者治疗后的王氏评分表评分高于治疗前,差异有统计学意义(P<0.05);联合治疗组患者治疗后的王氏评分表评分高于氯丙嗪组,差异有统计学意义(P<0.05)。两组患者治疗后的血Ca^(2+)、Na^(+)含量高于治疗前,差异有统计学意义(P<0.05)。联合治疗组患者治疗后的血Ca^(2+)、Na^(+)含量高于氯丙嗪组,差异有统计学意义(P<0.05)。联合治疗组患者的临床治疗总有效率为94.00%,高于氯丙嗪组的66.00%,差异有统计学意义(P<0.05)。结论在西医基础上联合旋覆代赭汤加减,能够对脑卒中后呃逆起到较好的治疗作用,可有效改善患者的半身不遂、呃逆等症状,平衡体内血Ca^(2+)、Na^(+)含量。
Objective To explore the clinical effect of Modified Xuanfu Daizhe Decoction combined with Western medicine in the treatment of hiccups after stroke.Methods A total of 100 patients with hiccup after stroke in the Department of Neurology of Shenyang Orthopaedic Hospital,Chengji Hospital from December 2018 to June 2019 were selected as the research objects.They were divided into Chlorpromazine group and combined treatment group by random number table method,50 cases in each group.Chlorpromazine group received routine clinical treatment,Chlorpromazine Hydrochloride 25 mg/time,twice a day,orally.Patients in the combined treatment group were given Modified Xuanfu Daizhe Decoction on the basis of Chlorpromazine group.The treatment period for both groups was 21 days.The scores of hemiplegia,slurred speech,crooked mouth,constant hiccups in the throat,general weakness and dull pain in the gastric cavity were compared between two groups before and after treatment.The Wang′s scale score and hiccup efficacy score were compared between two groups before and after treatment.The blood Ca^(2+)and Na^(+)levels of the two groups of patients before and after treatment were compared.The total effective rate was compared between the two groups.Results The scores of hemiplegia,slurred speech,crooked mouth,constant hiccups in the throat,general weakness and dull pain in the gastric cavity of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The scores of hemiplegia,slurred speech,crooked mouth,constant hiccups in the throat,general weakness and dull pain in the gastric cavity of patients in the combined treatment group were lower than those in the Chlorpromazine group after treatment,and the differences were statistically significant(P<0.05).The hiccup efficacy scores of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The hiccup efficacy score of patients in the combined treatment group after treatment was lower than that in the Chlorpromazine group,and the difference was statistically significant(P<0.05).The Wang′s scale scores of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The Wang′s scale score after treatment in the combined treatment group was higher than that in the Chlorpromazine group,the difference was statistically significant(P<0.05).The serum Ca^(2+)and Na^(+)levels of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The blood Ca^(2+)and Na^(+)levels of the patients in the combined treatment group were higher than those in the Chlorpromazine group after treatment,and the differences were statistically significant(P<0.05).The total effective rate of clinical treatment of patients in the combined treatment group was 94.00%,which was higher than 66.00%in the Chlorpromazine group,and the difference was statistically significant(P<0.05).Conclusion The application of Modified Xuanfu Daizhe Decoction on the basis of Western medicine treatment can have a better therapeutic effect on hiccups after stroke.It can effectively improve patients with hemiplegia,hiccups and other symptoms,and balance blood Ca^(2+)and blood Na^(+)levels in the body.
作者
于丽文
YU Li-wen(Department of Neurology,Shenyang Orthopedic Hospital,Chengji Hospital,Liaoning Province,Shenyang110000,China)
出处
《中国当代医药》
CAS
2021年第35期179-183,共5页
China Modern Medicine
关键词
旋覆代赭汤加减
脑卒中
呃逆
盐酸氯丙嗪
临床观察
Modified Xuanfu Daiyu Decoction
Stroke
Hiccup
Chlorpromazine hydrochloride
Clinical observation
