摘要
目的探讨涎腺超声评分法联合血清学指标在原发性干燥综合征(PSS)诊断中的临床意义。方法选择2017年6月至2018年6月临床可疑PSS患者101例,根据ACR/EULAR分类标准,将101例患者分为PSS组和非PSS组,通过受试者工作曲线下面积(AUROC),比较单独应用超声评分、血清学指标及两者联合应用诊断PSS的敏感度、特异度等。结果单独应用超声评分诊断PSS的AUROC为0.799,敏感度为78.85%,特异度为75.00%;单独应用血清学指标诊断PSS的AUROC为0.813,敏感度为82.69%,特异度为80.00%;两者联合应用诊断PSS的AUROC为0.869,敏感度为76.92%,特异度为92.50%。单独应用血清学指标与超声评分比较,两者对PSS的诊断效能差异无统计学意义(P>0.05);两者联合应用,与单独应用超声评分或血清学指标比较,联合应用能明显提高诊断效能(P<0.05)。结论联合应用超声评分和血清学指标能明显提高PSS的诊断效能,具有较高的临床应用价值。
Objective To investigate the clinical significance of salivary gland ultrasound scoring combined with serological indicators in the diagnosis of primary Sjogren′s syndrome(PSS).Methods A total of 101 patients with clinically suspected PSS from June 2017 to June 2018 were assigned to the PSS and non-PSS groups based on ACR/EULAR classification criteria.By means of the area under the receiver operating characteristic(AUROC),the sensitivity and specificity of the ultrasound scoring and serological indicators used separately and the combined application of the two were compared for the diagnosis of PSS.Results Of ultrasound scoring alone for diagnosis of PSS,the AUROC was 0.799;the sensitivity was 78.85%;the specificity was 75.00%.Of serological indicators alone for diagnosis of PSS,the AUROC was0.813;the sensitivity was 82.69%;the specificity was 80.00%.Of the combined application of ultrasound scoring and serological indicators for diagnosis of PSS,the AUROC was 0.869;the sensitivity was 76.92%;the specificity was 92.50%.No significant difference was observed in the diagnostic efficiency of PSS when using serological indicators and ultrasound scoring alone(P>0.05),but the combined application of serological indicators and ultrasound scoring alone could significantly improve the diagnostic efficiency of PSS(P<0.05).Conclusion The combined application of ultrasound scoring and serological indicators can significantly improve the diagnostic efficiency of PSS,which has high clinical application value.
作者
蒋佳纯
许世豪
王晓冰
陈斌
JIANG Jiachun;XU Shihao;WANG Xiaobing;CHEN Bin(Department of Ultrasound Imaging,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China;Department of Rheumatology and Immunology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)
出处
《中国现代医生》
2021年第31期131-134,F0003,共5页
China Modern Doctor
基金
浙江省卫生健康科技计划(2021KY789)
浙江省温州市基础性科研项目(Y20190680)。
关键词
涎腺
超声评分
原发性干燥综合征
血清学指标
Salivary gland
Ultrasound scoring
Primary Sjogren′s syndrome
Serological indicators
