摘要
目的总结23例女性生殖道浅表肌纤维母细胞瘤(superficial cervical vaginal myofibroblastoma,SCVM)病理形态及免疫组化特点,并分析其预后以及与其他疾病的诊断鉴别。方法回顾性分析郑州人民医院收治的23例SCVM患者的病理学特征和免疫学组化特点。结果本次23例患者中有20例为中度至强阳性表达desmin,表明大多数患者为瘤细胞弥漫强阳性表达vimentin。有15例ALK阳性,全部患者表达为ER和PR,有19例患者表达为CD34,此结果表明多数患者均可表达CD34,有5例患者表达α-SMA,有3例患者表达MSA,而不表达的则包括S-100蛋白、CD57、NF、GFAP和EMA。结论 SCVM具有独特的组织学形态,通过对免疫表型分析后发现瘤细胞具有肌纤维母细胞分化,其与其他女性生殖道肿瘤具有一定的相似性,病理医生要根据其病理形态和免疫组化特点进行分辨,以免误诊。
Objective To summarize the pathomorphology and immunohistochemical features of 23 cases of superficial myofibroblastoma of female reproductive tract(superficial cervical vaginal myofibroblastoma,SCVM),and to analyze its prognosis and differential diagnosis from other diseases.Methods The pathological and immunohistochemical features of 23 patients with SCVM treated in People’s Hospital of Zhengzhou were analyzed retrospectively.Results In this study,20 of the 23 patients showed moderate to strongly positive expression of desmin,indicating that most of thepatients were diffuse strongly positive expression of vimentin in tumor cells. There were 15 ALK positive patients,all of whom expressed ER and PR,and 19 of whom expressed CD34. The result table showed that most of the patients expressed CD34,5 of whom expressed α-SMA,3 of whom expressed MSA,while those who did not expressed S-100 protein CD57,NF, GFAP and EMA.Conclusions SCVM has unique histological morphology. Through the analysis of immunophenotype,it is found that tumor cells have myofibroblast differentiation,which is similar to other female reproductive tract tumors. Pathologists should distinguish them according to their pathological morphology and immunohistochemical characteristics to avoid misdiagnosis.
作者
冯海佳
李川
杨金花
FENG Hai-jia;LI Chuan;YANG Jin-hua(Department ofPathology,People's HospitalofZhengzhou,Zhengzhou 450003,China)
出处
《循证医学》
2021年第4期220-224,共5页
The Journal of Evidence-Based Medicine
基金
河南省医学攻关计划(联合共建)项目(LHGJ20191084)。
关键词
女性生殖道
浅表肌纤维母细胞瘤
病理形态
免疫组化
female reproductive tract
superficial cervical vaginal myofibroblastoma
pathomorphology
immunohistochemistry
