摘要
宫颈癌是我国最常见的女性生殖系统肿瘤之一,严重威胁女性的生命健康。HOX转录反义RNA(HOTAIR)是一种典型的反义长链非编码RNA,在宫颈癌细胞中的表达显著升高,与宫颈癌的发生发展密切相关。近年HOTAIR在宫颈癌发生发展中发挥作用的机制研究发现其抑制大量抑癌基因的表达,广泛参与宫颈癌细胞的增殖、凋亡、侵袭和迁移等各个环节,通过调节放疗耐受、抗逆转录和免疫靶向助力晚期宫颈癌治疗,在宫颈癌的遗传易感性中起着重要的作用,且与肿瘤进展及不良预后有显著相关性。未来根据HOTAIR的分子机制设计治疗靶点,通过大样本、多中心、前瞻性的临床试验证实其有效性和实用性,将为宫颈癌患者的早期诊断和个性化治疗提供新的思路。
Cervical cancer is one of the most common female reproductive system tumors in China,which seriously threatens women′s life and health.HOTAIR is a typical antisense long non-coding RNA,and its expression in cervical cancer cells is significantly increased,which is closely related to the occurrence and development of cervical cancer.In recent years,researches on the mechanism of HOTAIR in the occurrence and development of cervical cancer found that HOTAIR inhibits the expression of a large number of tumor suppressor genes,and is widely involved in the proliferation,apoptosis,invasion and migration of cervical cancer cells.HOTAIR assists the treatment of advanced cervical cancer by regulating the resistance to radiotherapy,anti-retroviral transcription and immune targeting.It plays an important role in the genetic susceptibility of cervical cancer,and has a significant correlation with tumor progression and poor prognosis.In the future,therapeutic targets will be designed according to the molecular mechanism of HOTAIR,and their effectiveness and practicability would be confirmed through large-sample,multi-center,prospective clinical trials,which will provide new ideas for the early diagnosis and personalized treatment of cervical cancer patients.
作者
顾轩妍
王新宇
GU Xuan-yan;WANG Xin-yu(Department of Gynecological Oncology,Women′s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China;Zhejiang Province Key Laboratory of Female Reproductive Health Research,Hangzhou 310006,China)
出处
《国际妇产科学杂志》
CAS
2021年第6期620-623,633,共5页
Journal of International Obstetrics and Gynecology
基金
浙江省科技计划项目(2020C03025)
国家重点研发计划(2016YFC1302900)。
