摘要
妊娠期糖尿病(gestational diabetes mellitus,GDM)是一种常见的妊娠期并发症,其发病率在全球范围内日益增高。目前临床上对GDM的诊疗手段仍存在一定的局限性,难以在妊娠前或妊娠早期及时发现并调整生活方式避免GDM的发生、发展。内源性多肽是生物体内普遍存在的一类生命活动调控物质,具有分子质量低、活性高、易于合成和改造等优点作为药物的良好分子基础,是近年来的研究热点。越来越多的研究表明内源性多肽在疾病的预测、诊断和治疗方面都发挥着重要作用,且其在GDM中的研究也日益受到更多的关注。就GDM相关多肽的研究进展进行了综述。
Gestational diabetes mellitus(GDM)is a common complication of pregnancy,and its incidence rate is increasing worldwide.At present,there are still some limitations in the diagnosis and treatment of GDM.It is difficult to find and adjust the unhealthy lifestyle before or in the early pregnancy period to avoid the occurrence and development of GDM.Endogenous polypeptides is a class of life regulating substances that exist in organisms.They have the advantages of low molecular weight,high activity and easy to synthesize and modificate.As a good molecular basis for drugs,they are becoming a research hotspot in recent years.More and more studies have shown that endogenous peptides plays an important role in the prediction,diagnosis and treatment of diseases,and their research in GDM has attracted more and more attention.This paper aims to review the research progress of GDM related peptides.
作者
殷亚东
刘岚
YIN Ya-dong;LIU Lan(Women′s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)
出处
《国际妇产科学杂志》
CAS
2021年第6期651-655,共5页
Journal of International Obstetrics and Gynecology
关键词
糖尿病
妊娠
糖尿病
2型
肽类
预测
治疗
Diabetes,gestational
Diabetes mellitus,type 2
Peptides
Forecasting
Therapy
