摘要
目的分析甲状腺乳头状癌(papillary thyroid carcinoma,PTC)与良性结节患者的临床特征差异。方法回顾性分析2017年7月1日至2020年7月31日期间在安徽医科大学第二附属医院耳鼻喉头颈外科一病区住院的215例甲状腺疾病患者的一般情况、临床检验资料、术后病理资料等,根据术后病理结果,将入选患者分为甲状腺良性结节组与甲状腺乳头状癌组。采用相应统计学方法比较两组患者在基本资料、临床检验结果之间的差异。结果纳入研究患者215例,其中,甲状腺良性结节患者121例(男27例,女94例),甲状腺乳头状癌患者94例(男30例,女64例);通过SPSS 23.0进行统计学分析。两组在年龄,TSH,TG(甲状腺球蛋白)方面的差异有统计学意义(P<0.05)。Logistic单因素回归分析结果提示,年龄≤45岁、TSH≥2.500 mIU/L、TG≤78.00 ng/mL为甲状腺乳头状癌的危险因素(P<0.05);多因素回归分析(向前似然比法)结果进一步发现,年龄≤45岁、TSH≥2.500 mIU/L、TG≤78.00 ng/mL为甲状腺乳头状癌的独立危险因素(P<0.05)。结论年龄≤45岁、TSH(≥2.500 mIU/L)、TG(≤78.00 ng/mL)为甲状腺乳头状癌的独立危险因素。
Objective to analyze the difference of clinical characteristics between papillary thyroid carcinoma and benign thyroid nodules.Methods Retrospective analysis was performed on the general conditions,clinical examination data,and postoperative pathological data of patients with thyroid diseases discharged from the first ward of Otolaryngology Head and Neck Surgery Department of our hospital on July 1,2017 and July 31,2020.According to the postoperative pathological results,the enrolled patients were divided into a benign thyroid nodule group and a papillary thyroid carcinoma group.The corresponding statistical methods were used to compare the differences between the two groups in basic data and clinical test results.Results A total of 215 patients with benign thyroid nodules(27 males and 94 females)and 94 patients with papillarythyroid carcinoma(30 males and 64 females)were included in the study.There were significant differences in age,TSH and TG(Thyroglobulin)between the two groups.The results of Logistic univariate regression analysis showed that age≤45 years old,TSH≥2.500 mIU/L and TG≤78.00 ng/mL were risk factors for papillary thyroid cancer,and multivariate regression analysis(forward likelihood ratio)further found that age≤45,TSH≥2.500 mIU/L and TG≤78.00 ng/mL were independent risk factors for papillary thyroid cancer.Conclusion Age≤45 years old,TSH≥2.500 mIU/L and TG≤78.00 ng/mL were independent risk factors for papillary thyroid cancer.
作者
赵振涛
梅金玉
ZHAO Zhentao;MEI Jinyu(The Second Hospital of Anhui Medical University,Hefei 230000,China)
出处
《邵阳学院学报（自然科学版）》
2021年第6期108-116,共9页
Journal of Shaoyang University：Natural Science Edition
基金
安徽医科大学校科研基金资助项目(2019xkj138)。
