摘要
目的观察柴胡桂枝汤治疗肝郁脾虚型慢性疲劳综合征(Chronic fatigue syndrome,CFS)临床疗效。方法选取2015年12月—2018年2月期间上海市中西医结合医院传统医学科门诊收治的CFS患者72例,随机分为治疗组和对照组,各36例。治疗组给予柴胡桂枝汤颗粒剂治疗,对照组予以服用安慰剂,两组患者均治疗28d,治疗结束后随访1个月。观察比较两组患者治疗前后及随访时疲劳量表(Fatigue scale-14,FS-14)、焦虑自评量表(Self-rating anxiety scale,SAS)、抑郁自评量表状态问卷(Self-rating depression scale,SDS)、中医证候积分、临床疗效及不良反应发生情况。结果治疗组治疗4周后、随访时FS-14评分明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗组治疗4周后、随访时SAS评分明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗组治疗2、4周后及随访时SDS评分明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗组治疗4周后、随访时中医证候量表评分明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后治疗组总有效率88.89%(32/36),对照组总有效率36.11%(13/36),两组比较,差异有统计学意义(P<0.05)。治疗期间,两组患者均未发现不良反应。结论运用柴胡桂枝汤治疗肝郁脾虚型CFS疗效确切,可以有效改善患者主要临床症状,明显缓解患者焦虑、抑郁等负面情绪,有助于患者生活质量的提高,在一定程度上对CFS起到防治作用。
Objective To study the effect of Chaihu Guizhi Decoction on chronic fatigue syndrome of liver depression and spleen deficiency,and to observe its clinical effect of emotional factors on Chronic Fatigue Syndrome.Methods From December 2015 to February 2018,72 patients with chronic fatigue syndrome who were admitted to the traditional medicine department of Shanghai Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into treatment group and control group,with 36 cases in each group.The treatment group was given Chaihu Guizhi Decoction granules,and the control group was given a placebo.Patients in both groups were treated for 28 days and followed up for 1 month after the treatment.After treatment,Fatigue Scale-14(FS-14)score,SAS score and SDS score,TCM syndrome score and clinical efficacy were compared between the two groups.Results After 4 weeks of treatment,the FS-14 score of the treatment group was significantly lower than that of the control group during follow-up.The difference between the two groups was statistically significant(P<0.05).After 4 weeks of treatment,the SAS score of the treatment group was significantly lower than that of the control group during follow-up.The difference between the two groups was statistically significant(P<0.05).The SDS score of the treatment group was significantly lower than that of the control group after 2 and 4 weeks of treatment and during follow-up.The difference between the two groups was statistically significant(P<0.05).The scores of the TCM Syndrome Scale in the treatment group were significantly lower than those in the control group after 4 weeks of treatment and during follow-up.The difference between the two groups was statistically significant(P<0.05).After treatment,the total effective rate of the treatment group was 88.89%(32/36),and the total effective rate of the control group was 36.11%(13/36).The difference between the two groups was statistically significant(P<0.05).During the treatment period,no adverse reactions were found in the two groups of patients.Conclusion The use of Chaihu Guizhi Decoction in the treatment of chronic fatigue syndrome with liver-stagnation and spleen-deficiency is effective,and can significantly relieve anxiety,depression and other negative emotions of patients,contributing to the improvement of patients’quality of life,and to the prevention and treatment of CFS to a certain extent.
作者
刘杰
胡粤杭
应汝炯
沈洁
盛昭园
LIU Jie;HU Yue-hang;YING Ru-jiong;SHEN Jie;SHENG Zhao-yuan(Department of Traditional Medicine,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 200082)
出处
《世界中西医结合杂志》
2021年第10期1908-1911,共4页
World Journal of Integrated Traditional and Western Medicine
基金
上海市卫生和计划生育委员会中医医疗机构综合治疗工作项目(ZY3-FWMS-2-1014)
上海市虹口区科学技术委员会(虹卫1602-04)。
关键词
柴胡桂枝汤
慢性疲劳综合征
肝郁脾虚证
Chaihu Guizhi Decoction
Chronic Fatigue Syndrome
Liver Stagnation and Spleen Deficiency Syndrome
