摘要
目的分析二氧化锆全瓷冠对前牙缺损修复患者龈沟肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)的影响。方法回顾性分析2018年10月至2020年10月航天中心医院口腔科收治的前牙缺损患者110例(196颗)的临床资料,参照其治疗方案进行分组,对照组55例(99颗)给予金合金烤瓷冠修复,观察组55例(97颗)给予二氧化锆全瓷冠修复。统计两组修复后的效果和并发症发生情况,检测两组咀嚼功能及龈沟液中TNF-α、IL-6、CRP水平。结果修复前,两组间咀嚼功能比较,差异无统计学意义(P>0.05);修复1个月后,两组咀嚼效率、咬牙合力均较修复前升高,观察组咀嚼效率、咬牙合力为0.21±0.06、(139.85±14.51)Ibs,优于对照组[0.32±0.13、(121.03±12.26)Ibs],差异均有统计学意义(P<0.05)。修复前,两组间龈沟液中TNF-α、IL-6、CRP水平比较,差异无统计学意义(P>0.05);两组修复1个月后龈沟液中TNF-α、IL-6、CRP水平均较修复前升高,且观察组修复1个月后龈沟液中TNF-α、IL-6、CRP为(739.55±57.26)pg/mL、(86.36±12.03)pg/mL、(29.63±9.14)mg/L,低于对照组[(814.22±63.35)pg/mL、(92.31±15.41)pg/mL、(34.21±11.02)mg/L],差异均有统计学意义(P<0.05)。观察组边缘密合度、修复体颜色、解剖外形、修复体折裂、牙龈状况等评价修复效果的等级指标均优于对照组,差异均有统计学意义(P<0.05)。两组疼痛、牙龈发炎、牙体腐蚀等并发症的发生率比较,差异无统计学意义(P>0.05)。结论二氧化锆全瓷冠修复前牙缺损可改善咀嚼功能,控制修复后龈沟液中TNF-α、IL-6、CRP等炎症因子的释放,提高修复效果。
Objective To analyze the effects of zirconia all-ceramic crowns on gingival crevicular tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in patients with anterior tooth defect repair.Methods The clinical data of 110 patients(196 teeth)with anterior teeth defect admitted to Space Center Hospital from October 2018 to October 2020 were retrospectively analyzed,and were divided into two groups according to their treatment plan.55 patients(99 teeth)in the control group were given gold alloy porcelain crown,55 cases(97 teeth)in the observation group were given zirconia all-ceramic crown restoration.The effects and complications of the two groups after repair were counted,and the differences in masticatory function and TNF-α,IL-6,and CRP in gingival crevicular fluid between the two groups were detected.Results Before restoration,there was no statistically significant difference between the mastication function groups(P>0.05).Compared with before restoration,the mastication efficiency and bite force of the two groups were increased after 1 month of restoration,and the chewing efficiency and bite force in the observation group after 1 month of restoration were 0.21±0.06,(139.85±14.51)Ibs,which were better than those in the control group[0.32±0.13,(121.03±12.26)Ibs],the differences were statistically significant(P<0.05).Before restoration,there was no significant difference in the levels of TNF-α,IL-6,CRP of gingival crevicular fluid between groups(P>0.05).Compared with before restoration,the levels of TNF-α,IL-6,CRP of gingival crevicular fluid between the two groups after 1 month of restoration were increased,and TNF-α,IL-6,CRP of the gingival crevicular fluid in the observation group were(739.55±57.26)pg/mL,(86.36±12.03)pg/mL,(29.63±9.14)mg/L,which were lower than control group[(814.22±63.35)pg/mL,(92.31±15.41)pg/mL,(34.21±11.02)mg/L],the differences were statistically significant(P<0.05).The edge fit,restoration color,anatomical shape,restoration fracture,gingival condition and other evaluation indexes of the restoration effect in the observation group’s were better than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications such as pain,gingival inflammation,and dental erosion between the two groups(P>0.05).Conclusion Zirconium dioxide all-ceramic crown repairing anterior tooth defect can improve the masticatory function,control the release of TNF-α,IL-6,CRP and other inflammatory factors in the gingival crevicular fluid after repair,and improve the repair effect.
作者
周磊
张艳芳
丁彤
杨瑟飞
宫春雨
ZHOU Lei;ZHANG Yan-fang;DING Tong(Department of Stomatology,Medical School of Chinese PLA,Beijing 100853,China;Department of Stomatology,the First Medical Centre,Chinese PLA General Hospital,Beijing 100853,China)
出处
《临床和实验医学杂志》
2021年第23期2571-2574,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金面上项目(编号:81371183)。
关键词
二氧化锆全瓷冠修复
前牙缺损
修复效果
咀嚼功能
Zirconium dioxide all-ceramic crown restoration
Anterior tooth defect
Repair effect
Chewing function
