摘要
目的分析鄱阳湖区晚期日本血吸虫病(晚血)发生的影响因素,为有效控制晚血的发生提供科学依据.方法收集2002年以后发生的晚血病例169例作为观察组,按性别相同、年龄和居住地相近等原则进行1∶1配对,以慢性血吸虫病病例(慢血)作为对照组;采用自行设计的问卷进行回顾性调查,内容包括研究对象基本信息、确诊慢血前后可能与晚血发生的相关因素,以及通过查治病分户册收集2002年以来的查、治病情况,共计20项指标.结果单因素分析显示,职业、职业改变、慢血后伴有消化系统疾病、查病间隔年限、服药依从性、累计服药次数、年间受检率、年间血阳检出率、年间粪阳检出率、年间治疗率等11项指标有统计学意义;logistic回归的多因素分析结果显示,离开疫源地累计年数越多、高暴露接触疫水方式的减少、累计服药次数越多是晚血发生的保护因素;而年间血阳检出率越高、高易感季节接触疫水、服药依从性越差、伴有乙肝是晚血发生的危险因素.结论在今后血吸虫病控制措施中,健全有效地血吸虫病病例追踪管理体系,改进影响晚血发生相关因素的干预措施.
To analyze the main influencing factors of advanced schistosomiasis(AS)in Poyang Lake region,so as to provide a scientific prevention gist for effective control of the AS occurrence.A total of 169 AS cases were selected as case group,and chronic cases were chosen as control group matched by gender,age and close residence at ratio of 1∶1 since 2002.A questionnaire with 20 indicators was used to conduct a retrospective survey.The survey content included the basic information of the participants,the factors related to the AS occurrence before and after the diagnosis of chronic schistosomiasis,as well as the data of examinations and treatments collected since 2002.Univariate analysis showed that occupation,occupational changes,concomitant diseases in the digestive system of chronic schistosomiasis,the interval years between examinations,medication compliance,cumulative number of medications,annual detection rate,annual positive rate of antibody detection,annual positive rate of stool examination,and annual medication rate etc.,totally 11 indicators,were statistically significant.The result of logistic regression showed that the cumulative years leaving endemic areas,the high risk exposure to infested water,and the cumulative medications are the protective factors for the AS occurrence,while the higher annual positive rate of antibody detection,the higher seasonal exposure to infested water,the poorer medication compliance,and concomitant with hepatitis B were risk factors.To establish an effective schistosomiasis case tracking management system,and strengthen intervention measures of the risk factors may effectively control the occurrence of advanced schistosomiasis.
作者
黄兴华
谢曙英
金海辉
宁安
胡飞
HUANG Xing-hua;XIE Shu-ying;JIN Hai-hui;NING An;HU Fei(Yugan County Station of Schistosomiasis Control,Jiangxi Province,Yugan 335100,China;Jiangxi Provincial Institute of Parasitic Diseases,Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control,Nanchang 330046,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2021年第12期1129-1134,共6页
Chinese Journal of Zoonoses
基金
国家自然科学基金(No.71764011,No.81860371)
江西省重点研发计划(No.20181BBG70033,No.20202BBGL73047)
江西省重点实验室计划项目(No.20192BCD40006)
江西省自然科学基金(No.20202BABL206118)联合资助。
