摘要
目的:研究外周血肿瘤异常蛋白(TAP)联合鳞状细胞癌抗原(SCCA)、薄层液基细胞学检查(TCT)在宫颈癌筛查中的应用价值。方法:根据病理学检查结果将72例宫颈病变患者分为宫颈癌组(n=22)和癌前病变组(n=50),并选择同期进行宫颈癌筛查的31名健康者作为对照组。比较所有研究对象外周血TAP、SCCA水平和TCT阳性率,并分析其与宫颈病变程度的相关性。采用受试者工作特征曲线(ROC)分析外周血TAP联合SCCA、TCT对宫颈癌的筛查价值。结果:三组研究对象外周血TAP、SCCA水平及TCT阳性率比较,宫颈癌组>癌前病变组>对照组(P<0.05);不同宫颈癌病变程度患者外周血TAP、SCCA水平比较,宫颈癌>CINⅢ级>CINⅡ级>CINⅠ级(P<0.05);外周血TAP、SCCA水平均分别与宫颈病变程度呈正相关(P<0.05);随着组织学病理级别的增加,宫颈病变患者TCT结果阳性率也逐渐升高(P<0.05);外周血TAP、SCCA、TCT均对宫颈癌具有定的筛查价值,但三者联合的AUC值及特异度较单一指标升高(P<0.05)。结论:外周血TAP联合SCCA及TCT用于宫颈癌及癌前病变的筛查,可显著提高特异度,并评估宫颈病变程度。
Objective:To study the application value of peripheral blood tumor abnormal protein(TAP)combined with squamous cell carcinoma antigen(SCCA)and thinprep cytology test(TCT)in cervical cancer screening.Methods:A total of 72 patients with cervical lesions were selected,and divided into cervical cancer group and precancerous lesion group based on pathological results.Meanwhile,31 normal healthy people who received cervical cancer screening during the same period were selected as the control group.Peripheral blood TAP and SCCA levels,and TCT positive rates in the three groups were comparatively analyzed.The correlation between above-mentioned indicators and the degree of cervical lesions was analyzed.The receiver operating characteristic curve(ROC)was used to analyze the value of peripheral blood TAP combined with SCCA and TCT in cervical cancer screening.Results:Peripheral blood TAP and SCCA levels,and TCT positive rate decreased in sequence from the cervical cancer group,the precancerous lesion group to the control group(P<0.05).Peripheral blood TAP and SCCA levels in patients with different cervical lesions showed cervical cancer>CINⅢ>CINⅡ>CINⅠ,with statistically significant differences(P<0.05).Peripheral blood TAP and SCCA levels were positively correlated with the degree of cervical lesions(P<0.05).As histopathological grade increased,the positive rate of TCT results in patients with cervical lesions increased(P<0.05).Peripheral blood TAP,SCCA,and TCT all could be used for cervical cancer screening,and the AUC value and specificity of the three in combination were significantly higher(P<0.05).Conclusion:Peripheral blood TAP combined with SCCA and TCT can significantly improve the specificity and evaluate the degree of cervical lesions.
作者
黄东静
HUANG Dong-jing(Department of Obstetrics,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,Liaoning,China)
出处
《川北医学院学报》
CAS
2021年第12期1565-1568,共4页
Journal of North Sichuan Medical College
基金
辽宁省自然科学基金(2014020127)。
关键词
宫颈癌
癌前病变
肿瘤异常蛋白
鳞状细胞癌抗原
薄层液基细胞学检查
Cervical cancer
Precancerous lesion
Tumor abnormal protein
Squamous cell carcinoma antigen
Thinprep cytology test
