摘要
目的探讨川芎嗪保留灌肠治疗溃疡性结肠炎(UC)的临床疗效。方法68例UC患者按照数字随机表法分为观察组和对照组,每组各34例。对照组在常规治疗的基础上给予美沙拉唤肠溶片口服,观察组在对照组的基础上给予川芎嗪温水灌肠治疗。比较治疗前后两组的结肠黏膜病变情况、疾病活动指数(DAI)评分、炎症因子水平、内皮功能、血小板凝溶胶蛋白(gelsolin)、血小板黏附率(PADT)以及营养指标水平,观察两组的不良反应发生情况。结果治疗后,观察组的Baron内镜评分、DAI评分显著低于本组治疗前及对照组治疗后(P<0.05);观察组的IL-6、TNF-α、NF-KB水平显著低于本组治疗前及对照组治疗后(P<0.05),IL-10水平显著高于本组治疗前及对照组治疗后(P<0.05);观察组的ET-1、gelsolin、PADT水平显著低于本组治疗前及对照组治疗后(P<0.05),NO显著高于本组治疗前及对照组治疗后(P<0.05);观察组的TP、Hb、Alb、PA水平显著高于本组治疗前及对照组治疗后(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论川芎嗪保留灌肠治疗UC疗效较好,可抑制肠道炎症反应,保护血管内皮,改善微循环功能及营养状态,缓解血液高凝情况,且安全性较高。
Objective To explore the clinical effect of ligustrazine retention enema on ulcerative coliris(UC).Methods 68 UC patients were divided into observation group and control group according to the numerical random table method,with 34 patients in each group.The control group was treated with conventional treatment and mesalazine enteric-coated tablets orally,while the observation group was treated with ligustrazine warm water enema on the basis of the control group.The colonic mucosal lesions,disease activity index(DAI)scores,levels of inflammatory factors,endothelial function,platelet geLsolin,platelet adhesion rate(PADT),nutritional indexes,and the incidence of adverse reactions in the two groups were observed.Results After treatment,Baron endoscopy score and DAI score in the observation group were significantly lower than before and those after treatment in the control group(P<0.05).After treatment,the levels of IL-6,TNF-α and NF-KB in the observation group were significantly lower than before and after treatment those in the control group(P<0.05),the level of IL-10 was significantly higher than before and that of the control group after treatment(P<0.05).After treatment,the levels of ET-1,gelsolin and PADT in the observation group were significantly lower than those before and after treatment(P<0.05),and NO was significantly higher than those before and after treatment(P<0.05).After treatment,the levels of TP,Hb,Alb and PA in the observation group were significantly higher than before and those after treatment in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ligustrazine retention enema has good efficacy in the treatment of UC,which can inhibit intestinal inflammatory response,protect vascular endothelium,improve microcirculation flincrion and nutritional status,relieve hypercoagulability of blood,and the security ls high.
出处
《浙江临床医学》
2021年第12期1779-1781,共3页
Zhejiang Clinical Medical Journal
关键词
川芎嗪
灌肠
溃疡性结肠炎
血小板活化
Ligustrazine
Enema
Ulcerative colitis
Platelet activation
